6,6a,7,8,9,10-hexahydro-5H-pyrido[1,2-a]quinoxaline

Base Information

• Chemical Name: 6,6a,7,8,9,10-hexahydro-5H-pyrido[1,2-a]quinoxaline
• CAS No.: 1414960-54-5
• Molecular Formula: C₁₂H₁₆N₂
• Molecular Weight: 188.272
• Mol file: 1414960-54-5.mol

Synonyms:

Chemical Property of 6,6a,7,8,9,10-hexahydro-5H-pyrido[1,2-a]quinoxaline

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

(R)-6,6a,7,8,9,10-Hexahydro-5H-pyrido[1,2-a]quinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,6a,7,8,9,10-hexahydro-5H-pyrido[1,2-a]quinoxaline

There total 5 articles about 6,6a,7,8,9,10-hexahydro-5H-pyrido[1,2-a]quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

7,8,9,10-tetrahydro-6aH-5-oxypyrido[1,2-a]quinoxalin-6-ylamine (755743-81-8) → 6,6a,7,8,9,10-hexahydro-5H-pyrido[1,2-a]quinoxaline (1414960-54-5)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; at 20 ℃; for 168h; under 3750 Torr;

DOI:10.1002/1099-0690(200103)2001:5<987::AID-EJOC987>3.0.CO;2-B

Reference yield:

piperidine (110-89-4) → 6,6a,7,8,9,10-hexahydro-5H-pyrido[1,2-a]quinoxaline (1414960-54-5)

Guidance literature:

Multi-step reaction with 4 steps

2: 89 percent / LiClO₄ / methanol / Electrochemical reaction

3: 91 percent / H₂ / Pearlman's catalyst / dioxane / 48 h / 20 °C / 735 Torr

4: 56 percent / H₂ / Pearlman's catalyst / methanol / 168 h / 20 °C / 3750 Torr

With hydrogen; lithium perchlorate; palladium dihydroxide; In 1,4-dioxane; methanol;

DOI:10.1002/1099-0690(200103)2001:5<987::AID-EJOC987>3.0.CO;2-B

Reference yield:

1-(2-nitrophenyl)piperidine (15822-77-2) → 6,6a,7,8,9,10-hexahydro-5H-pyrido[1,2-a]quinoxaline (1414960-54-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / LiClO₄ / methanol / Electrochemical reaction

2: 91 percent / H₂ / Pearlman's catalyst / dioxane / 48 h / 20 °C / 735 Torr

3: 56 percent / H₂ / Pearlman's catalyst / methanol / 168 h / 20 °C / 3750 Torr

With hydrogen; lithium perchlorate; palladium dihydroxide; In 1,4-dioxane; methanol;

DOI:10.1002/1099-0690(200103)2001:5<987::AID-EJOC987>3.0.CO;2-B

upstream raw materials:

7,8,9,10-tetrahydro-6aH-5-oxypyrido[1,2-a]quinoxalin-6-ylamine

piperidine

1-(2-nitrophenyl)piperidine

ortho-nitrofluorobenzene

Refernces