2,3-Diphenylquinoxalin-6-amine

Base Information

• Chemical Name: 2,3-Diphenylquinoxalin-6-amine
• CAS No.: 7466-46-8
• Molecular Formula: C20H15 N3
• Molecular Weight: 297.359
• Hs Code.: 2933990090
• NSC Number: 402619
• DSSTox Substance ID: DTXSID90322985
• Nikkaji Number: J81.402D
• Wikidata: Q82081784
• ChEMBL ID: CHEMBL1517505
• Mol file: 7466-46-8.mol

Synonyms:2,3-diphenylquinoxalin-6-amine;7466-46-8;6-Amino-2,3-diphenylquinoxaline;MLS001201591;NSC 402619;SMR000640983;NSC402619;ChemDiv1_028677;Oprea1_208859;cid_345195;2,3-diphenyl-6-quinoxalinamine;CHEMBL1517505;SCHEMBL11792682;BDBM53192;HMS668H11;2,3-Diphenyl-6-aminoquinoxaline;DTXSID90322985;(2,3-diphenylquinoxalin-6-yl)amine;AKOS000678932;CCG-106285;NSC-402619;EU-0071140;SR-01000409993;SR-01000409993-1;F0914-1625

Chemical Property of 2,3-Diphenylquinoxalin-6-amine

Chemical Property:

• Vapor Pressure: 3.77E-09mmHg at 25°C
• Boiling Point: 473.9°C at 760 mmHg
• Flash Point: 271.8°C
• PSA: 51.80000
• Density: 1.224g/cm³
• LogP: 5.12720
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 297.126597491
• Heavy Atom Count: 23
• Complexity: 373

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)N)N=C2C4=CC=CC=C4

Technology Process of 2,3-Diphenylquinoxalin-6-amine

There total 10 articles about 2,3-Diphenylquinoxalin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-nitro-2,3-diphenylquinoxaline (7466-45-7) → 2,3-diphenyl-6-amino-quinoxaline (7466-46-8)

Guidance literature:

With 5% Pd(II)/C(eggshell); hydrogen; In ethanol; at 20 ℃;

DOI:10.1016/j.bmcl.2011.02.055

Reference yield: 99.0%

benzil (134-81-6) + benzene-1,2,4-triamine (615-71-4) → 2,3-diphenyl-6-amino-quinoxaline (7466-46-8)

Guidance literature:

In methanol; acetic acid; at 160 ℃; for 0.0833333h; Irradiation;

DOI:10.1016/j.tetlet.2004.04.144

Reference yield:

4-Nitrophenylene-1,2-diamine (99-56-9) → 2,3-diphenyl-6-amino-quinoxaline (7466-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 24 h / Heating

2: H₂ / Pd/C / ethanol / 3 h / 20 °C

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/j.bmcl.2007.01.094

upstream raw materials:

6-nitro-2,3-diphenylquinoxaline

ethanol

benzil

benzene-1,2,4-triamine

Downstream raw materials:

C₂₁H₁₃N₃O

1-(4-chlorophenyl)-3-(2,3-diphenylquinoxalin-6-yl)urea

Refernces

• 1、 Sagar, Satish,Singh, Sarbjit,Mallareddy, Jayapal Reddy,Sonawane, Yogesh A.,Napoleon, John V.,Rana, Sandeep,Contreras, Jacob I.,Rajesh, Christabelle,Ezell, Edward L.,Kizhake, Smitha,Garrison, Jered C.,Radhakrishnan, Prakash,Natarajan, Amarnath. "Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy". . . Retrieved 2021/06/22.
• 2、 Chandra Shekhar,Shanthan Rao,Narsaiah,Allanki, Aparna Devi,Sijwali, Puran Singh. "Emergence of pyrido quinoxalines as new family of antimalarial agents". . p. 280 - 287. Retrieved 2014/04/03.