615-71-4Relevant articles and documents
Synergistic effect from Lewis acid and the Ni-W2C/AC catalyst for highly active and selective hydrogenation of aryl nitro to aryl amine
Zhao, Zhongkui,Yang, Hongling,Li, Yu
, p. 22669 - 22677 (2014)
This work presents a facile approach for clean and chemoselective synthesis of various functionalized arylamines from their corresponding substituted nitroarenes through the unexpected synergistic effect of a Lewis acid and the Ni-W2C/AC catalyst, affording almost 100% arylamine yield. The results challenge the long-held axiom that the combination of Lewis acid and hydrogenation catalyst mainly enhances the transformation of nitrobenzene (NB) to p-aminophenol via Bamberger rearrangement of the formed intermediate phenylhydroxylamine (PHA) under catalytic hydrogenation conditions. X-ray diffraction (XRD) and FT-IR spectroscopy were employed to reveal the relationship between catalyst nature and catalytic performance, and a plausible reaction mechanism is also proposed. Reaction results demonstrate that the FeCl3-Ni-W2C/AC catalytic system shows comparable catalytic performance towards precious metals for chemoselective reduction of various aromatic nitro compounds, affording 100% yield for all substrates involved in this work (99.5% of isolated yield for model substrate). Moreover, it can be found that the catalyst could be easily recovered by filtration and recycled without visible loss of its catalytic activity. Therefore, the developed FeCl3-Ni-W2C/AC catalytic system in this work can be considered as a practical candidate for clean and highly-efficient synthesis of diverse functionalized arylamines. We believe this approach can be extended to the other hydrogenation reactions. This journal is the Partner Organisations 2014.
Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy
Bian, Yuanyuan,Chen, Yadong,Hong, Qianqian,Jiang, Fei,Kong, Bo,Li, Hongmei,Lu, Tao,Ma, Yu,Ran, Ting,Tang, Weifang,Wang, Cong,Yang, Na,Zhang, Zhimin,Zheng, Wan,Zhu, Jiapeng,Zhu, Zhaohong
, (2021/11/03)
As epigenetic readers, bromodomain and extra-terminal domain (BET) family proteins bind to acetylated-lysine residues in histones and recruit protein complexes to promote transcription initiation and elongation. Inhibition of BET bromodomains by small molecule inhibitors has emerged as a promising therapeutic strategy for cancer. Herein, we describe our efforts toward the discovery of a novel series of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as BET inhibitors. Intensive structural modifications led to the identification of compound 35f as the most active inhibitor of BET BRD4 with selectivity against BET family proteins. Further biological studies revealed that compound 35f can arrest the cell cycle in G0/G1 phase and induce apoptosis via decreasing the expression of c-Myc and other proteins related to cell cycle and apoptosis. More importantly, compound 35f showed favorable pharmacokinetic properties and antitumor efficacy in MV4-11 mouse xenograft model with acceptable tolerability. These results indicated that BET inhibitors could be potentially used to treat hematologic malignancies and some solid tumors.
Ionic liquid covered iron-oxide magnetic nanoparticles decorated zeolite nanocomposite for excellent catalytic reduction and degradation of environmental toxic organic pollutants and dyes
Alarifi, Saud,Ali, Daoud,Arumugam, Vasanthakumar,Chandrasekaran, Murugesan,Dass, Avitha,Gao, Yanan,Gengan, Robert M,Moodley, Kandasamy G
, (2021/09/20)
Ionic liquid 2′,3′-epoxypropyl-N-methyl-2-oxopyrrolidinium salicylate ([EPMpyr][SAL]) IL, bonded iron oxide magnetic nanoparticles (MNP) with zeolite modified nanocomposite (IL/MNP/Zeo) was synthesized. This nanocomposite was characterized by micro and macroscopic techniques, namely, Fourier transform infrared spectroscopy (FTIR), x-ray powder diffraction (XRD), scanning electron microscope (SEM), energy dispersive x-ray spectrometry (EDX), transmission electron microscopy (TEM), thermogravimetry and differential scanning calorimetry (TGA&DSC). These techniques have been used to reveal the overall physical properties including functional groups which are present, crystalline nature, morphology, elemental identifications and thermal stability of the nanocomposite respectively. In this case, ionic liquid (IL) and iron oxide magnetic nanoparticles (MNP) were synthesized and characterized. Both IL and MNPs contributed to enhancing the binding property and thermal stability of the nanocomposite. This novel nanocomposite acts as an excellent catalyst for the reduction of several nitroanilines, namely, 2-nitroaniline, 3-nitroaniline, 4-nitroaniline, Nitrophenyl diamine and dyes (Methylene blue and Allura red). In this investigation, time-dependent UV–vis spectroscopy was used to monitor the reduction reactions. Furthermore, the catalyst was removed after completion of the reaction, using an external magnet; then purified and recycled for further reactions with negligible loss of activity. In addition, these reduction reactions are obtained in an aqueous medium which makes them more economical, eco-friendly and easy to handle. This type of research is very helpful in environmental protection; especially the pollution of natural water resources from industrial wastewater.
Novel perovskite nanocatalyst (BiFeO3) for the photodegradation of rhodamine B/tartrazine and swift reduction of nitro compounds
Singh, Harminder,Rajput, Jaspreet Kaur
, p. 2409 - 2432 (2019/07/03)
Design and synthesis of visible light respondent photocatalyst with high separation efficiency is of great importance due to its application in practical point of view. In this presentation, novel perovskite-structured BiFeO3 nanoparticles have been successfully synthesized by simple, cost-effective and eco-friendly technique. The BiFeO3 nanoparticles were prepared by using different chelating agents (sucrose, citric acid, tartaric acid and urea) and under different range of calcination temperature (150–850?°C). Different characterization techniques such as FT-IR, XRD, VSM, BET, TEM and UV–Vis spectroscopy have been used for its structure evaluation. Further, by using this catalyst, a green approach has been developed for the removal of harmful organic compounds from the industrial waste. The catalytic activity was assessed by the catalytic degradation of industrial waste dyes such as rhodamine B and tartrazine (first time by perovskite-structured material) in aqueous media under sunlight irradiation and reduction of various nitro compounds to corresponding amines (in s) by using NaBH4 in green solvent water at room temperature. Effect of all types of BiFeO3 nanoparticles on catalytic degradation and reduction was investigated. BiFeO3 nanoparticles prepared by sucrose as chelating agent and calcinated at 650° were selected as a better catalyst on the basis of its performance in degradation and reduction experiment. Thus, the present approach provides a promising way to prepare noble catalyst for extensive applications in degradation/reduction of organic pollutants. The examination of degraded products of dye has been carried out by using FT-IR; mass spectroscopy and UV–Vis spectroscopy and confirmation of reduction of nitrocompounds with UV–Vis spectroscopy.
