4-chloro-2-(dichloromethyl)quinazoline

Base Information

• Chemical Name: 4-chloro-2-(dichloromethyl)quinazoline
• CAS No.: 88203-16-1
• Molecular Formula: C9H5 Cl3 N2
• Molecular Weight: 247.511
• Mol file: 88203-16-1.mol

Synonyms:NSC 377824

Chemical Property of 4-chloro-2-(dichloromethyl)quinazoline

Chemical Property:

• Vapor Pressure: 0.0207mmHg at 25°C
• Boiling Point: 259.7°C at 760 mmHg
• Flash Point: 135.9°C
• Density: 1.529g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-2-(dichloromethyl)quinazoline

There total 2 articles about 4-chloro-2-(dichloromethyl)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

dichloroacetonitrile (3018-12-0) + anthranilic acid nitrile (1885-29-6) → 4-Chloro-2-dichloromethylquinazoline (88203-16-1)

Guidance literature:

hydrogenchloride; In 1,4-dioxane; for 12h; Ambient temperature;

Reference yield: 10.0%

4-chloro-2-(trichloromethyl)quinazoline (3137-63-1) + phenylacetylene (536-74-3) → 1,4-diphenyl-1,3-butadiyne (886-66-8) + 4-phenylethynyl-2-trichloromethyl-quinazoline (1427059-64-0) + 1,1,2,2-Tetrachloro-1,2-bis(4-chloroquinazolin-2-yl)ethane (1427059-65-1) + 4-Chloro-2-dichloromethylquinazoline (88203-16-1)

Guidance literature:

With copper(l) iodide; palladium diacetate; caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Reagent/catalyst; Solvent; Time; Temperature; Inert atmosphere;

DOI:10.1016/j.tet.2013.01.094

Reference yield: 42.0%

4-Chloro-2-dichloromethylquinazoline (88203-16-1) + 2,4-Dichloroaniline (554-00-7,51908-09-9) → 2-dichloromethyl-N-(2,4-dichlorophenyl)quinazolin-4-amine

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 70 ℃; for 2h;

DOI:10.1016/j.ejmech.2016.09.029

upstream raw materials:

dichloroacetonitrile

anthranilic acid nitrile

4-chloro-2-(trichloromethyl)quinazoline

phenylacetylene

Refernces

• 1、 Shishoo, C. J.,Devani, M. B.,Bhadti, V. S,Jain, K. S.,Ananthan, S.. "Reaction of Nitriles under Acidic Conditions. Part VI. Synthesis of Condensed 4-Chloro- and 4-Aminopyrimidines from ortho-Aminonitriles". . p. 119 - 126. Retrieved 2007/10/02.