5-FLUORO-2-PIPERIDIN-1-YL-PHENYLAMINE

Base Information

• Chemical Name: 5-FLUORO-2-PIPERIDIN-1-YL-PHENYLAMINE
• CAS No.: 252758-87-5
• Molecular Formula: C11H15FN2
• Molecular Weight: 194.252
• Mol file: 252758-87-5.mol

Synonyms:

Chemical Property of 5-FLUORO-2-PIPERIDIN-1-YL-PHENYLAMINE

Chemical Property:

• PSA: 29.26000
• LogP: 3.04440

Purity/Quality:

98%min ^*data from raw suppliers

5-fluoro-2-piperidin-1-ylaniline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 5-FLUORO-2-PIPERIDIN-1-YL-PHENYLAMINE

There total 3 articles about 5-FLUORO-2-PIPERIDIN-1-YL-PHENYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-fluoro-2-nitro-phenyl)-piperidine (719-70-0) → 5-fluoro-2-(piperidin-1-yl)aniline (252758-87-5)

Guidance literature:

1-(4-fluoro-2-nitro-phenyl)-piperidine; With hydrogenchloride; tin(ll) chloride; In methanol; at 0 - 20 ℃; for 21h;

With water; sodium hydrogencarbonate; In methanol;

Reference yield:

piperidine (110-89-4) → 5-fluoro-2-(piperidin-1-yl)aniline (252758-87-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere

2: tin(II) chloride dihdyrate / ethanol / 1 h / 70 °C / Inert atmosphere

With tin(II) chloride dihdyrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.9b00293

Reference yield:

1,4-difluoro-2-nitrobenzene (364-74-9) → 5-fluoro-2-(piperidin-1-yl)aniline (252758-87-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere

2: tin(II) chloride dihdyrate / ethanol / 1 h / 70 °C / Inert atmosphere

With tin(II) chloride dihdyrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.9b00293

upstream raw materials:

1-(4-fluoro-2-nitro-phenyl)-piperidine

piperidine

1,4-difluoro-2-nitrobenzene

Refernces

• 1、 Maben, Zachary,Arya, Richa,Rane, Digamber,An, W. Frank,Metkar, Shailesh,Hickey, Marc,Bender, Samantha,Ali, Akbar,Nguyen, Tina T.,Evnouchidou, Irini,Schilling, Roger,Stratikos, Efstratios,Golden, Jennifer,Stern, Lawrence J.. "Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1". . p. 103 - 121. Retrieved 2020/02/20.