- Promazine
- Promazine hydrochloride
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Cas Database |
| Name |
Promazine hydrochloride |
EINECS | 200-179-7 |
| CAS No. | 53-60-1 | Density | 1.1435 (rough estimate) |
| PSA | 31.78000 | LogP | 5.10800 |
| Solubility | N/A | Melting Point |
174-176 °C |
| Formula | C17H20N2S.HCl | Boiling Point | 412.7 °C at 760 mmHg |
| Molecular Weight | 320.886 | Flash Point | 203.4 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | 36 | Risk Codes | 22-43 |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
Phenothiazine,10-[3-(dimethylamino)propyl]-, monohydrochloride (8CI);Esparinal;Liranol;Prolactyl;Promwill;Sparine; |
Article Data | 3 |
Promazine hydrochloride Consensus Reports
Reported in EPA TSCA Inventory.
Promazine hydrochloride Safety Profile
Poison by ingestion, subcutaneous, intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion: general anesthesia, tremors, antipsychotic effects. An additive permitted in food for human consumption; also permitted in the feed and drinking water of animals and/or for the treatment of food-producing animals.
Promazine hydrochloride Specification
The IUPAC name of Promazine hydrochloride is N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine hydrochloride. With the CAS registry number 53-60-1, it is also named as 10-(3-(Dimethylamino)propyl)phenothiazine hydrochloride; 10-H-Phenothiazine-10-propanamine, N,N-dimethyl-, monohydrochloride; Chlorowodorek promazyny; Phenothiazine, 10-(3-(dimethylamino)propyl)-, hydrochloride; Sparine.
The Promazine hydrochloride is an active pharmaceutical ingredient. It is soluble in water, methanol, ethanol, chloroform, but insoluble in benzene and ether. When heated to decomposition it emits toxic fumes of NOx, SOx, and HCl. This product is harmful if swallowed. It may cause sensitization by skin contact. If you want to contact this product, you must wear suitable protective clothing.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 4.63; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.6; (4)ACD/LogD (pH 7.4): 2.67; (5)ACD/BCF (pH 5.5): 1.8; (6)ACD/BCF (pH 7.4): 21.22; (7)ACD/KOC (pH 5.5): 7.28; (8)ACD/KOC (pH 7.4): 85.72; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Enthalpy of Vaporization: 66.54 kJ/mol; (13)Vapour Pressure: 5.08E-07 mmHg at 25°C; (14)Rotatable Bond Count: 4; (15)Exact Mass: 320.111397; (16)MonoIsotopic Mass: 320.111397; (17)Topological Polar Surface Area: 31.8; (18)Heavy Atom Count: 21.
People can use the following data to convert to the molecule structure. SMILES: Cl.S2c1ccccc1N(c3c2cccc3)CCCN(C)C; InChI: InChI=1/C17H20N2S.ClH/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19;/h3-6,8-11H,7,12-13H2,1-2H3;1H. Promazine hydrochloride has many Changzhou Ilhang Fine Chemical Co., Ltd. and Changzhou Xixialong International Co., Ltd..
The following is the toxicity data which has been tested.
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intramuscular | 4400ug/kg (4.4mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. -, 1965. | |
| human | TDLo | oral | 20mg/kg/D-I (20mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: TREMOR BEHAVIORAL: ANTIPSYCHOTIC | Journal of Nervous and Mental Disease. Vol. 123, Pg. 553, 1956. |
| mouse | LD50 | intramuscular | 28mg/kg (28mg/kg) | Annales Pharmaceutic. Vol. 13, Pg. 51, 1978. | |
| mouse | LD50 | intravenous | 38mg/kg (38mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 42, 1972. | |
| mouse | LD50 | subcutaneous | 300mg/kg (300mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 42, 1972. | |
| rabbit | LD50 | intravenous | 21mg/kg (21mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 42, 1972. | |
| rat | LD50 | intravenous | 29mg/kg (29mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 42, 1972. | |
| rat | LD50 | oral | 400mg/kg (400mg/kg) | Fortschritte der Arzneimittelforschung. Progress in Drug Research. Vol. 5, Pg. 269, 1963. | |
| rat | LDLo | intraperitoneal | 356mg/kg (356mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Journal of Pharmaceutical Sciences. Vol. 54, Pg. 295, 1965. |
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