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Name Propantheline bromide
EINECS200-030-6
CAS No. 50-34-0
Density1.2916 (rough estimate)
PSA35.53000
LogP1.73480
Solubilitywater: >=10 g/100 mL at 21 °C
Melting Point159-161 °C
FormulaC₂₃H₃₀NO₃^.Br
Boiling PointN/A
Molecular Weight448.4
Flash PointN/A
Transport InformationN/A
Appearancewhite crystalline powder
Safety36
Risk Codes22
Molecular Structure
Hazard SymbolsXn
SynonymsXn

Propantheline bromide Synthetic route

: 74-83-9
methyl bromide

xanthene-9-carboxylic acid <2-diisopropylamino-ethyl ester: xanthene-9-carboxylic acid <2-diisopropylamino-ethyl ester

: 50-34-0
propantheline bromide

Conditions

Conditions	Yield
With chloroform

: 50-34-0
propantheline bromide

: 82-07-5
xanthene-9-carboxylic acid

Conditions

Conditions	Yield
With water at 100℃; for 1.16667h; pH=7.0; Kinetics; Further Variations:; pH-values;

: 16836-95-6
silver(I) 4-methylbenzenesulfonate

: 50-34-0
propantheline bromide

: 1107608-70-7
propantheline p-toluenesulfonate

Conditions

Conditions	Yield
In acetonitrile at 20℃; Darkness;

Propantheline bromide Chemical Properties

Propantheline bromide ,its CAS register number is 50-34-0,it's called for Ammonium,diisopropyl(2-hydroxyethyl)methyl-,bromide,xanthene-9-carboxylate ; Diisopropyl(2-hydroxyethyl)methylammoniumbromidexanthene-9-carboxylate ; Ercorax ; Ercotina ; Iumbromide ; Ketaman ; Kivatin ; Nci-c56257 ; Pantheline ; Probantine ; Prodixamon ; Corrigast ,and so on. Propantheline bromide (CAS No.50-34-0) is usually white crystals or white powder.

IUPAC Name: Methyl-di(propan-2-yl)-[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium bromide
CAS: 50-34-0
Molecular Formula: C₂₃H₃₀BrNO₃
Molecular Weight: 448.39
Molecular structure:
EINECS: 200-030-6
Melting point: 159-161°C
Water solubility: >=10 g/100 mL at 21 ºC
ACD/LogD (pH 5.5): -1.77
ACD/LogD (pH 7.4): -1.77
ACD/BCF (pH 5.5): 1
ACD/BCF (pH 7.4): 1
ACD/KOC (pH 5.5): 2.61
ACD/KOC (pH 7.4): 2.61
H bond acceptors: 4
H bond donors: 0

Propantheline bromide Uses

1. Propantheline bromide (CAS No.50-34-0) is mainly used as an antimuscarinic agent for the treatment of excessive sweating (hyperhidrosis), cramps or spasms of the stomach, intestines (gut) or bladder, involuntary urination (enuresis), etc.
2. Propantheline bromide (CAS No.50-34-0) is also used to control the symptoms of irritable bowel syndrome and similar conditions.

Propantheline bromide Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	intravenous	51mg/kg (51mg/kg)		Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 151, Pg. 614, 1957.
mouse	LD50	intraperitoneal	60mg/kg (60mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969.
mouse	LD50	intravenous	6400ug/kg (6.4mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA	Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959.
mouse	LD50	oral	445mg/kg (445mg/kg)		Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 319, 1970.
mouse	LD50	subcutaneous	128mg/kg (128mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969.
rabbit	LD50	oral	750mg/kg (750mg/kg)		Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 36, 1973.
rat	LD50	intraduodenal	125mg/kg (125mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.
rat	LD50	intraperitoneal	25mg/kg (25mg/kg)		Compilation of LD50 Values of New Drugs.
rat	LD50	intravenous	4mg/kg (4mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959.
rat	LD50	oral	370mg/kg (370mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.
rat	LD50	subcutaneous	298mg/kg (298mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.

RTECS: BP8249200

Propantheline bromide Safety Profile

Hazard Codes: Xn
Risk Statements: 22 (R22:Harmful if swallowed.)
Safety Statements: 36 (S36:Wear suitable protective clothing.)

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Product Name

Propantheline bromide

Propantheline bromide Synthetic route

Propantheline bromide Chemical Properties

Propantheline bromide Uses

Propantheline bromide Toxicity Data With Reference

Propantheline bromide Safety Profile

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