Analytical Methods: | | For occupational chemical analysis use NIOSH: Strychnine, 5016.
Risk CodesR27/28;R50/53
Molecular Structure
Hazard Symbols
Synonyms
Article Data25
STRYCHNINE Chemical PropertiesSynonyms: 2,4a,5,5a,7,8,15,15a,15b,15c-decahydro-4,6-methano-6h,14h-indolo[3,2,1-ij]oxep; (-)-STRYCHNINE;STRYCHNINE;Strychnidin-10-one;STRYCHNINE ALKALOID;Vauquline;L-STRYCHNINE; STRYCHNINE(57-24-9) is the chemical compound with the formula C 21H 22N 2O 2.Its molar mass is 334.41,and melting point 284-286 °C. The Molecular Structure of STRYCHNINE(57-24-9): STRYCHNINE HistoryIn 1818,Strychnine(57-24-9) was first isolated from the beans of Strychnos ignatii by Pierre Joseph Pelletier and Joseph Bienaimé Caventou . Its structure was determined by Sir Robert Robinson and Herman Leuchs in 1946. In 1952, Robinson wrote that "For its molecular size it is the most complex substance known." STRYCHNINE Toxicity Data With ReferenceThe toxicity of STRYCHNINE(57-24-9): 1. | | ims-rat TDLo:500 µg/kg (5D preg):REP | | PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 100 (1959),555. | 2. | | orl-hmn LDLo:30 mg/kg | | PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc. (Topeka, KS.: )1966,1073. | 3. | | orl-man LDLo:30 mg/kg | | PEMNDP Pesticide Manual. 9 (1991),771. | 4. | | orl-man LDLo:5143 mg/kg | | JTCTDW Journal of Toxicology, Clinical Toxicology. 30 (1992),269. | 5. | | orl-rat LD50:2350 µg/kg | | JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. 31 (1942),113. | 6. | | ipr-rat LD50:1100 µg/kg | | JPETAB Journal of Pharmacology and Experimental Therapeutics. 58 (1936),239. | 7. | | scu-rat LD50:1200 µg/kg | | RPTOAN Russian Pharmacology and Toxicology. Translation of FATOAO. 31 (1968),260. | 8. | | ivn-rat LD50:582 µg/kg | | CHHTAT Zhonghua Yixue Zazhi. Chinese Medical Journal. 54 (1974),234. | 9. | | orl-mus LD50:2 mg/kg | | IJEBA6 Indian Journal of Experimental Biology. 19 (1981),1075. | 10. | | ipr-mus LD50:980 µ |
STRYCHNINE Consensus ReportsReported in EPA TSCA Inventory. EPA Extremely Hazardous Substances List. STRYCHNINE Safety ProfileHuman poison by ingestion. Experimental poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. Experimental reproductive effects. An allergen. Lethal dose to man: 30–60 mg/kg. If ingested, the time of action depends upon the condition of the stomach, whether empty or full, and the nature of the food present. If taken by subcutaneous injection, the place of administration of the injection will affect the time of action. The first symptoms are a feeling of uneasiness with a heightened reflex of irritability, followed by muscular twitching in some parts of the body. With larger doses, this is followed by a sense of impending suffocation. Convulsive movements begin that have the effect of mechanically causing the patient to cry out or to shriek; then follow the characteristic spasms, which set in with violence. These are at first clonic and then tonic. There are successive attacks of spasms. With each successive attack, the symptoms become more violent, eventually resulting in death. A rodenticide. When heated to decomposition it emits toxic fumes of NOx. STRYCHNINE Standards and RecommendationsThe standards of STRYCHNINE: OSHA PEL: TWA 0.15 mg/m3 ACGIH TLV: TWA 0.15 mg/m3 DFG MAK: 0.15 mg/m3 DOT Classification: 6.1; Label: Poison STRYCHNINE Analytical MethodsThe analyticalmethods of STRYCHNINE(57-24-9): For occupational chemical analysis use NIOSH: Strychnine, 5016.
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