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Basic information

  • Name:
  • Sodium nitrite

  • CAS No.:
  • 7632-00-0

  • Formula:
  • NaNO2
  • Synonyms:
  • Natrium nitrit;Nitrous acid sodium salt;Dusitan sodny;Anti-Rust;Nitrite de sodium;Diazotizing salts;Erinitrit;NCI-C02084;Filmerine;Synfat 1004;Nitrous acid, sodium salt;M 138C;Sodium Nitrite for Industrial use;Industrial Sodium Nitrite;
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Chemistry

Structure of Sodium Nitrite (CAS NO.7632-00-0):

IUPAC Name: sodium nitrite 
Empirical Formula: NNaO2
Molecular Weight: 68.9953 
EINECS: 231-555-9 
Melting Point: 271 °C(lit.)
Boiling Point: 320 °C
Density: 1.29 g/mL at 25 °C
Storage temp: 2-8°C
Solubility aqueous acid: 1 - 2μl acetic acid per ml H2Osoluble
Water Solubility: 820 g/L (20 ºC)
Sensitive: Hygroscopic 
Physical Appearance: white to off-white powder
Stability: Stable. Incompatible with reducing agents, strong oxidizing agents, organics and other flammable materials, finely powdered metals. Contact with combustible material may lead to fire. Hygroscopic. 
Product Categories: Sodium nitrile;Inorganics;Water Ttreatment Chemicals;ACS GradeSynthetic Reagents;Essential Chemicals;Routine Reagents;Other AdditivesVolumetric Solutions;Reference Material Potassium permanganateVolumetric Solutions;Allergens;By Reference Material;Cosmetics;S - Z;Salt Solutions;Q-S, Puriss p.a. ACS;Analytical Reagents for General Use;Puriss p.a. ACS;Inorganic Salts;Salts;Sodium Salts;SodiumMetal and Ceramic Science;Synthetic Reagents

Uses

 Sodium Nitrite (CAS NO.7632-00-0) is used as a color fixative and preservative in meats and fish. It is also used in manufacturing diazo dyes, nitroso compounds, and other organic compounds; in dyeing and printing textile fabrics and bleaching fibers;  in metal coatings for phosphatizing and detinning; in photography; as a laboratory reagent and a corrosion inhibitor;and in the manufacture of rubber chemicals. Sodium nitrite may also be used as an electrolyte in electrochemical grinding manufacturing processes, typically diluted to about 10% concentration in water. Sodium nitrite also has been used in human and veterinary medicine as a vasodilator, a bronchodilator, and an antidote for cyanide poisoning.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 1500mg/kg (1500mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935.
cat LDLo subcutaneous 35mg/kg (35mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 126, Pg. 209, 1927.
chicken LD50 oral 28944ug/kg (28.944mg/kg)   American Journal of Veterinary Research. Vol. 30, Pg. 2185, 1969.
child LDLo oral 22mg/kg (22mg/kg) VASCULAR: OTHER CHANGES Lancet. Vol. 2, Pg. 162, 1917.
dog LDLo intravenous 15mg/kg (15mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 245, 1973.
dog LDLo oral 330mg/kg (330mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 245, 1973.
dog LDLo subcutaneous 60mg/kg (60mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 21, Pg. 425, 1911.
frog LDLo subcutaneous 1gm/kg (1000mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935.
human LDLo oral 71mg/kg (71mg/kg) BEHAVIORAL: COMA

GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 543, 1969.
human TDLo oral 14mg/kg (14mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

GASTROINTESTINAL: NAUSEA OR VOMITING
Deutsche Medizinische Wochenschrift. Vol. 74, Pg. 961, 1949.
man LDLo oral 321mg/kg (321mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN
Israel Journal of Medical Sciences. Vol. 28, Pg. 289, 1992.
man TDLo oral 1714ug/kg/70M (1.714mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Clinical Investigation. Vol. 16, Pg. 73, 1937.
mouse LD50 intraperitoneal 158mg/kg (158mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 165, Pg. 30, 1969.
mouse LD50 oral 175mg/kg (175mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 97, 1974.
mouse LDLo subcutaneous 150mg/kg (150mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: NAUSEA OR VOMITING
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 480, 1929.
rabbit LD50 oral 186mg/kg (186mg/kg)   Southwestern Veterinarian. Vol. 27, Pg. 246, 1974.
rabbit LDLo intravenous 80mg/kg (80mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: COMA

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 121, 1931.
rabbit LDLo subcutaneous 60mg/kg (60mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935.
rat LC50 inhalation 5500ug/m3/4H (5.5mg/m3)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 16(10), Pg. 36, 1972.
rat LD50 intravenous 65mg/kg (65mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 320, 1963.
rat LD50 oral 180mg/kg (180mg/kg)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat LD50 subcutaneous 96600ug/kg (96.6mg/kg)   Archives of Toxicology, Supplement. Vol. 14, Pg. 231, 1991.

Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Safety Profile

Hazard Codes: OxidizingO,ToxicT,DangerousN,HarmfulXn
Risk Statements: 8-25-50-22-36/38 
R8 :Contact with combustible material may cause fire. 
R25 :Toxic if swallowed. 
R50:Very toxic to aquatic organisms. 
R22:Harmful if swallowed. 
R36/38:Irritating to eyes and skin.
Safety Statements: 45-61-36-26 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets. 
S36:Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 3219 5.1/PG 3
WGK Germany: 3
RTECS: RA1225000
F: 10
HazardClass: 5.1
PackingGroup: III
HS Code: 28341000
Human poison by ingestion. Experimental poison by ingestion, inhalation, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: motor activity changes, coma, decreased blood pressure with possible pulse rate increase without fall in blood pressure, arteriolar or venous dilation, nausea or vomiting, and blood methemoglobinemia-carboxyhemoglobinemia. Experimental teratogenic and reproductive effects. An eye irritant. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Human mutation data reported. It may react with organic amines in the body to form carcinogenic nitrosamines.
Flammable; a strong oxidizing agent. In contact with organic matter, will ignite by friction. May explode when heated to over 1000°F or on contact with cyanides, NH4+ salts, cellulose, Li, (K + NH3), Na2S2O3. Incompatible with aminoguanidine salts, butadiene, phthalic acid, phthalic anhydride, reductants, sodium amide, sodium disulfite, sodium thiocyanate, urea wood. When heated to decomposition it emits toxic fumes of NOx and Na2O. See also NITRITES.

Standards and Recommendations

DOT Classification:  5.1; Label: Oxidizer

Specification

  Sodium Nitrite , its cas register number is 7632-00-0. It also can be called Anti-rust ; Azotyn sodowy ; Diazotizing salts ;
 Dusitan sodny ; Erinitrit ; Filmerine ; Natrium nitrit ; Nitrite de sodium ; Nitrito sodico .

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