Basic information
- Name:
Tamsulosin
- CAS No.:
106133-20-4
- Molecular Structure:
- Formula:
- C20H28N2O5S
- Molecular Weight:
- 408.51
- Synonyms:
- Benzenesulfonamide,5-[(2R)-2-[[2-(2-ethoxyphenoxy) ethyl]amino]propyl]-2-methoxy-;Amsulosin;Tamsulosine [INN-French];Tamsulosinum [INN-Latin];Tamsulosina [INN-Spanish];5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzenesulfonamide;Benzenesulfonamide, 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-, (R)-;(R)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide;Tamsulosin Hydrochloride;
- Density:
- 1.191 g/cm3
- Melting Point:
- 226-228 °C
- Boiling Point:
- 595.5 °C at 760 mmHg
- Flash Point:
- 313.9 °C
- Solubility:
- sparingly soluble in water and methanol
- Appearance:
- White crystals
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Specification
The Tamsulosin , with cas registry number of 106133-20-4, belongs to the classification codes of (1)adrenergic agents ; (2)adrenergic antagonists ; (3)adrenergic alpha-antagonists ; (4)antineoplastic agents ; (5)neurotransmitter agents. It is also called (R)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide ; Benzenesulfonamide, 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-, (R)- . Its IUPAC name is 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide . Its systematic name is 5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide .
Physical properties of Tamsulosin are: (1) ACD/LogP: 2.24 ; (2) # of Rule of 5 Violations: 0 ; (3) ACD/LogD (pH 5.5): -0.66 ; (4) ACD/LogD (pH 7.4): 0.79 ; (5) ACD/BCF (pH 5.5): 1 ; (6) ACD/BCF (pH 7.4): 1.06 ; (7) ACD/KOC (pH 5.5): 1 ; (8) ACD/KOC (pH 7.4): 14.13 ; (9) #H bond acceptors: 7 ; (10) #H bond donors: 3 ; (11) #Freely Rotating Bonds: 11 ; (12) Index of Refraction: 1.553 ; (13) Molar Refractivity: 109.78 cm3 ; (14) Molar Volume: 342.8 cm3 ; (15) Surface Tension: 45.2 dyne/cm ; (16) Density: 1.191 g/cm3 ; (17) Flash Point: 313.9 °C ; (18) Enthalpy of Vaporization: 88.74 kJ/mol ; (19) Boiling Point: 595.5 °C at 760 mmHg ; (20) Vapour Pressure: 3.79E-14 mmHg at 25°C.
Uses of Tamsulosin : this chemical has been used as a drug. It is an alpha 1 adrenoreceptor blocker which is used for treatment of benign prostatic hyperplasia and kidney stones.
You can still convert the following datas into molecular structure:
(1) SMILES:O=S(=O)(N)c1c(OC)ccc(c1)C[C@H](NCCOc2ccccc2OCC)C;
(2) InChI:InChI=1/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1;
(3) InChIKey:DRHKJLXJIQTDTD-OAHLLOKOBW