Basic Information | Post buying leads | Suppliers |
Name |
Terazosin hydrochloride |
EINECS | N/A |
CAS No. | 63074-08-8 | Density | 1.332 g/cm3 |
PSA | 103.04000 | LogP | 1.64090 |
Solubility | 25 mg/mL in water | Melting Point |
N/A |
Formula | C19H26ClN5O4 | Boiling Point | 664.5 °C at 760 mmHg |
Molecular Weight | 423.8938 | Flash Point | 355.7 °C |
Transport Information | N/A | Appearance | N/A |
Safety | 26-36 | Risk Codes | 22-36/37/38 |
Molecular Structure | Hazard Symbols | Xn | |
Synonyms |
Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-,monohydrochloride (9CI);1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazinemonohydrochloride;2-[4-(Tetrahydro-2-furoyl)-piperazine]-4-amino-6,7-dimethoxyquinazoline-hydrochloride;Abbott 45975;Dysalfa;Flotrin;Flumarc;Heitrin;Hitrin;Hytracin;Hytrin;Hytrine;Hytrinex;Itrin;Olyster;Rotiaz;Teralfa;Terasin;Terazosinhydrochloride;Tructum;Vasocard;Vasomet;Vicard; |
The Tetrazosin hydrochloride, with the CAS registry number 63074-08-8, has the IUPAC name of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](tetrahydrofuran-2-yl)methanone hydrochloride (1:1). It is a kind of white to off-white powder, and belongs to following the product categories: Pharmaceutical; (Intermediate of levofloxacin); Terazosin; Adrenoceptor. And the molecular formula of the chemical is C19H26ClN5O4.
The physical properties of Tetrazosin hydrochloride are as followings: (1)ACD/LogP: -0.96; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.95; (4)ACD/LogD (pH 7.4): -1.01; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 6.42; (9)#H bond acceptors: 9; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 80.26 Å2; (13)Flash Point: 355.7 °C; (14)Enthalpy of Vaporization: 97.72 kJ/mol; (15)Boiling Point: 664.5 °C at 760 mmHg; (16)Vapour Pressure: 1.59E-17 mmHg at 25°C.
You should be cautious while dealing with this chemical. It is harmful if swallowed, and it also irritates to eyes, respiratory system and skin. Therefore, you had better take the following instructions: Wear suitable protective clothing, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(N3CCN(c2nc1cc(OC)c(OC)cc1c(n2)N)CC3)C4OCCC4.Cl
(2)InChI: InChI=1/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H
(3)InChIKey: IWSWDOUXSCRCKW-UHFFFAOYAA
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rat | LD50 | intravenous | 277mg/kg (277mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Drug and Chemical Toxicology. Vol. 7, Pg. 435, 1984. |