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Terazosin hydrochloride

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Name

Terazosin hydrochloride

EINECS N/A
CAS No. 63074-08-8 Density 1.332 g/cm3
PSA 103.04000 LogP 1.64090
Solubility 25 mg/mL in water Melting Point N/A
Formula C19H26ClN5O4 Boiling Point 664.5 °C at 760 mmHg
Molecular Weight 423.8938 Flash Point 355.7 °C
Transport Information N/A Appearance N/A
Safety 26-36 Risk Codes 22-36/37/38
Molecular Structure Molecular Structure of 63074-08-8 (1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride) Hazard Symbols HarmfulXn
Synonyms

Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-,monohydrochloride (9CI);1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazinemonohydrochloride;2-[4-(Tetrahydro-2-furoyl)-piperazine]-4-amino-6,7-dimethoxyquinazoline-hydrochloride;Abbott 45975;Dysalfa;Flotrin;Flumarc;Heitrin;Hitrin;Hytracin;Hytrin;Hytrine;Hytrinex;Itrin;Olyster;Rotiaz;Teralfa;Terasin;Terazosinhydrochloride;Tructum;Vasocard;Vasomet;Vicard;

 

Terazosin hydrochloride Specification

The Tetrazosin hydrochloride, with the CAS registry number 63074-08-8, has the IUPAC name of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](tetrahydrofuran-2-yl)methanone hydrochloride (1:1). It is a kind of white to off-white powder, and belongs to following the product categories: Pharmaceutical; (Intermediate of levofloxacin); Terazosin; Adrenoceptor. And the molecular formula of the chemical is C19H26ClN5O4.

The physical properties of Tetrazosin hydrochloride are as followings: (1)ACD/LogP: -0.96; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.95; (4)ACD/LogD (pH 7.4): -1.01; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 6.42; (9)#H bond acceptors: 9; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 80.26 Å2; (13)Flash Point: 355.7 °C; (14)Enthalpy of Vaporization: 97.72 kJ/mol; (15)Boiling Point: 664.5 °C at 760 mmHg; (16)Vapour Pressure: 1.59E-17 mmHg at 25°C.

You should be cautious while dealing with this chemical. It is harmful if swallowed, and it also irritates to eyes, respiratory system and skin. Therefore, you had better take the following instructions: Wear suitable protective clothing, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.    

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(N3CCN(c2nc1cc(OC)c(OC)cc1c(n2)N)CC3)C4OCCC4.Cl
(2)InChI: InChI=1/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H
(3)InChIKey: IWSWDOUXSCRCKW-UHFFFAOYAA

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 intravenous 277mg/kg (277mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Drug and Chemical Toxicology. Vol. 7, Pg. 435, 1984.
 

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