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Cas Database |
| Name |
Tropacaine hydrochloride |
EINECS | N/A |
| CAS No. | 637-23-0 | Density | N/A |
| PSA | 29.54000 | LogP | 3.20850 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C15H19 N O2 . Cl H | Boiling Point | 339.9oC at 760 mmHg |
| Molecular Weight | 281.782 | Flash Point | 122.3oC |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx and HCl. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
8-Azabicyclo[3.2.1]octan-3-ol,8-methyl-, benzoate (ester), hydrochloride, exo-; Tropacocaine, hydrochloride(7CI); NSC 76018; Pseudotropine benzoate hydrochloride |
Article Data | 2 |
Tropacaine hydrochloride Synthetic route
| Conditions | Yield |
|---|---|
| Stage #1: benzoyl chloride; pseudotropine With potassium tert-butylate In tetrahydrofuran at 20 - 30℃; for 2.5h; Stage #2: With hydrogenchloride In tetrahydrofuran; diethyl ether; ethanol | |
| Stage #1: benzoyl chloride; pseudotropine With potassium tert-butylate In tetrahydrofuran at 20 - 30℃; for 2.5h; Stage #2: With hydrogenchloride In diethyl ether; ethanol |
- 637-23-0
Tropacocaine hydrochloride
- 18470-33-2, 20811-95-4, 123202-90-4
Nortropacocaine
| Conditions | Yield |
|---|---|
| With sodium perchlorate; water; sodium carbonate pH=10; pH-value; Electrochemical reaction; Green chemistry; | 81% |
| Conditions | Yield |
|---|---|
| With ammonia In water | |
| With ammonia In water |
Tropacaine hydrochloride Chemical Properties
IUPAC Name: (8-Methyl-8-azabicyclo[3.2.1]octan-3-yl) benzoate hydrochloride
CAS: 637-23-0
Following is the Molecular Structure of Tropacaine hydrochloride (637-23-0):
SMILES: Cl.O=C(OC2CC1N(C)C(CC1)C2)c3ccccc3
InChI: InChI=1/C15H19NO2.ClH/c1-16-12-7-8-13(16)10-14(9-12)18-15(17)11-5-3-2-4-6-11;/h2-6,12-14H,7-10H2,1H3;1H
InChIKey: MMAGCXHWOMQWKW-UHFFFAOYAB
Std.InChI: InChI=1S/C15H19NO2.ClH/c1-16-12-7-8-13(16)10-14(9-12)18-15(17)11-5-3-2-4-6-11;/h2-6,12-14H,7-10H2,1H3;1H
Std.InChIKey: MMAGCXHWOMQWKW-UHFFFAOYSA-N
Molecular Formula: C15H19NO2.ClH
Molecular Weight: 281.7778
Boiling Point: 339.9℃ at 760mmHg
Flash Point: 122.3℃
Enthalpy of Vaporization: 58.34kJ/mol
Vapour Pressure: 8.92E-05mmHg at 25℃
Tropacaine hydrochloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | subcutaneous | 465mg/kg (465mg/kg) | Research Communications in Substances Abuse. Vol. 5, Pg. 279, 1984. | |
| mouse | LDLo | intraperitoneal | 350mg/kg (350mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 227, 1934. |
| mouse | LDLo | intravenous | 42mg/kg (42mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936Vol. -, Pg. -, 1936. |
Tropacaine hydrochloride Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route.It's an experimental teratogen.
Tropacaine hydrochloride Specification
Tropacaine hydrochloride (637-23-0) also can be called for Tropacocaine hydrochloride ; Tropacocaine (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) benzoate ; Tropacaine hydrochloride ; 1-alpha-h,5-alpha-H-Tropan-3-alpha-ol,benzoate(ester),hydrochloride ; 8-Azabicyclo(3.2.1)octan-3-ol,8-methyl-, benzoate (ester),hydrochloride,ex benzoylpseudotropine hydrochloride ; O-benzoyltropine hydrochloride ; Pseudotropine benzoate hydrochloride ; Tropacocain hydrochloride .When Tropacaine hydrochloride (637-23-0) was heated,it emits toxic fumes of NOx and HCl .
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