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Product Name: Zearalenone (17924-92-4)
Molecular Formula: C18H22O5
Molecular Weight: 318.36g/mol
Mol File: 17924-92-4.mol
Einecs: 241-864-0
Appearance: Crystalline solid
Melting Point: 164-165°C
Boiling point: 600.4 °C at 760 mmHg
Storage Temperature: -20°C
Flash Point: 219.5 °C
Density: 1.168 g/cm3
Product Categories: Aromatic Ketones (substituted); Chiral Reagents; Intermediates and Fine Chemicals; Isotope Labeled Compounds; Pharmaceuticals; Estrogen ModulatorsCell Signaling and Neuroscience; MoldCancer Research; Cancer Research; Chemopreventive Agents; Phytoestrogens; Toxins and Venoms; Tumor Growth Regulation; CRM and Matrix RMBiotoxins; NeatApplication CRMs; Biotoxins; Food and Agriculture CRM; Mycotoxins; Other
Synonyms of Zearalenone (17924-92-4): (e)-(s)-2,4-Dihydroxy-7-methyl-7,8,9,10,13,14-hexahydro-12h-6-oxa-benzocyclotetradecene-5,11-dione ; 3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1h-2-benzoxacyclotetradecin-1,7(8h)-dione;mycotoxin f2 ; Zon ; Zenone ; Zearalenone ; (10s)-Zearalenone ; (e)--Methyl-7-oxo .
Estrogenic mycotoxin is produced by Fusarium fungi commonly found in grains. One of a group of compounds is known as resorcylic acid lactones.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
domestic animals - goat/sheep | LD50 | oral | > 5mg/kg (5mg/kg) | Veterinary and Human Toxicology. Vol. 25, Pg. 335, 1983. | |
mouse | LD | oral | > 2gm/kg (2000mg/kg) | National Toxicology Program Technical Report Series. Vol. NTP-TR-235, Pg. 1982, | |
mouse | LD50 | intraperitoneal | 5mg/kg (5mg/kg) | Veterinary and Human Toxicology. Vol. 25, Pg. 335, 1983. | |
rat | LD50 | oral | > 16gm/kg (16000mg/kg) | Toxicology and Applied Pharmacology. Vol. 37, Pg. 144, 1976. |
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 31 ,1983,p. 279.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 31 ,1983,p. 279.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NTP Carcinogenesis Bioassay (feed); Clear Evidence: mouse NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. 206- NTP-TR-235 ,1982. ; (feed); No Evidence: rat NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. 206- NTP-TR-235 ,1982. . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic, tumorigenic, and teratogenic data. Mutation data reported. A severe skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Flash point data for Zearalenone are not available. Zearalenone is probably combustible.
Safety Information of Zearalenone (17924-92-4):
Hazard Codes: C,Xn,F
Risk Statements: 34-62-63-36-20/21/22-11
11: Highly Flammable
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
34: Causes burns
36: Irritating to the eyes
62: Possible risk of impaired fertility
63: Possible risk of harm to the unborn child
Safety Statements: 26-36/37/39-45-36-16-36/37
16: Keep away from sources of ignition - No smoking
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)