Reference

Telomerized polyamides

Telomerized polyamides. (PPG Industries, Inc., USA). Japan. Kokai JP 51125018 1 Nov 1976 Showa, 17 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07C103-30. APPLICATION: JP 72-126325 18 Dec 1972. DOCUMENT TYPE: Patent CA Section: 36 (Plastics Manufacture and Processing) Radiation-curable telomerized diacryloylpolyamides are prepd. by reaction of acrylic acid or its derivs. with the reaction product of aminocarboxylic acids or lactams, satd. aliph. dicarboxylic acids, and satd. aliph. diamines. Thus, 159 parts of 8-aminooctanoic acid [1002-57-9] was heated at 200.degree. to remove 18 parts water, heated 1 h at 200.degree. with 12.5 parts succinic anhydride [108-30-5], reacted 2 h with 7.5 parts ethylenediamine [107-15-3], and reacted at 110.degree. with DMF 1700, acrylic anhydride [2051-76-5] 31.5, and tert-butylcatechol 1 part to give a telomerized polyamide [CH2:CHCONHCH2CH2NHCOCH2CH2CO[NH(CH2)7CO]nNHCH2C H2NHCOCH:CH2, n = .apprx.8] [62859-01-2], which became infusible upon exposure to electron beams.

Synthesis and properties of NBD-n-acylcholines, fluorescent analogs of acetylcholine

Synthesis and properties of NBD-n-acylcholines, fluorescent analogs of acetylcholine. Meyers, Hans Wilhelm; Juerss, Rolf; Brenner, Hans R.; Fels, Gregor; Prinz, Heino; Watzke, Heidrun; Maelicke, Alfred (Max-Planck-Inst. Ernaehrungsphysiol., Dortmund D-4600, Fed. Rep. Ger.). Eur. J. Biochem., 137(3), 399-404 (English) 1983.There are some reagents with their cas registry numbers 89160-48-5 and 1002-57-9 are used in this study. CODEN: EJBCAI. ISSN: 0014-2956. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2, 28 Synthesis of a homologous series of fluorescent analogs of acetylcholine, N-7-(4-nitrobenzo-2-oxa-1,3-diazolyl)-w-amino-n-alkanoic acid b-(N,N,N-trialkylammonium)ethyl esters (BD-n-acylcholines) is reported along with their physiol. and biochem. properties. All NBD-n-acylcholines trimethylated at the cholinergic N are agonists of acetylcholine at the frog neuromuscular junction. Their potencies in depolarizing frog muscle cells decrease with decreasing chain length. The affinities of binding to the purified receptor from Electrophorus electricus also decrease with decreasing chain length with a large drop in affinity for the derivs. n = 4 and n = 3. The rate consts. of assocn. to acetylcholine receptor and to acetylcholine esterase [9000-81-1] are of the order of 108 M-1 s-1 and do not vary significantly with the chain length of the NBD-n-acylcholines. In contrast, the dissocn. rate consts. decrease with increasing chain length. The quenching of fluorescence of NBD-n-acylcholines accompanying binding to purified receptor and esterase from E. electricus appears to be due to the formation of a H-bond between the w-amino group as donor and an unidentified acceptor group in a hydrophobic pocket of the protein. With their advantageous fluorescence properties, their simple pharmacol., and their clear structure-function relationships, these compds. are useful tools for the study of cholinergic mechanisms. .