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CAS No.: | 106447-97-6 |
---|---|
Name: | 2-Amino-4-(trifluoromethyl)pyridine |
Article Data: | 14 |
Molecular Structure: | |
Formula: | C6H5F3N2 |
Molecular Weight: | 162.114 |
Synonyms: | (4-Trifluoromethylpyridin-2-yl)amine;2-Amino-4-trifluoromethylpyridine;4-(Trifluoromethyl)pyridin-2-amine;2-Amino-4-(trifluoromethyl)pyridine; |
EINECS: | -0 |
Density: | 1.368 g/cm3 |
Melting Point: | 70-74 °C |
Boiling Point: | 221.338 °C at 760 mmHg |
Flash Point: | 87.662 °C |
Hazard Symbols: | T,Xi,C |
Risk Codes: | 25-36/37/38-43 |
Safety: | 26-36/37-45-36/37/39 |
Transport Information: | UN 2811 6.1/PG 3 |
PSA: | 38.91000 |
LogP: | 2.26380 |
2-chloro-4-trifluoromethyl pyridine
2-amino-4-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With ammonia In water at 170℃; for 24h; | 76% |
With ammonium hydroxide at 180℃; | |
With ammonium hydroxide | |
With ammonia |
2,6-dichloro-4-(trifluoromethyl)pyridine
2-amino-4-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
Stage #1: 2,6-dichloro-4-(trifluoromethyl)pyridine With ammonia In tetrahydrofuran; water at 150℃; for 6h; autoclave; Stage #2: With hydrogen; 5%-palladium/activated carbon In tetrahydrofuran; water at 100℃; under 15001.5 Torr; for 3h; Product distribution / selectivity; | 71.9% |
5-ethoxy-3-hydroxy-3-(trifluoromethyl)pent-4-enenitrile
2-amino-4-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With ammonia In water at 125℃; under 10501.1 Torr; for 24h; Autoclave; | 68% |
2-amino-4-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With acetamidine hydrochloride; sodium hydroxide In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; chemoselective reaction; | 61% |
2-amino-5-bromo-4-(trifluoromethyl)pyridine
bis(pinacol)diborane
A
4-(trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaboroloan-2-yl)pyridin-2-amine
B
2-amino-4-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 115℃; for 8h; Inert atmosphere; | A 48% B n/a |
With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane at 115℃; for 8h; | |
With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane at 115℃; for 8.25h; Heating / reflux; | |
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 115℃; for 8h; Inert atmosphere; |
2-amino-4-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With hydrogenchloride Hydrolysis; |
1-oxido-4-(trifluoromethyl)pyridin-1-ium
2-amino-4-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: CH2Cl2 / Heating 2: conc. HCl View Scheme |
2,6-dichloro-4-(trifluoromethyl)pyridine
A
4-(trifluoromethyl)pyridine-2,6-diamine
B
2-amino-4-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
Stage #1: 2,6-dichloro-4-(trifluoromethyl)pyridine With ammonia In water at 150℃; for 15h; autoclave; Stage #2: With hydrogen; 5%-palladium/activated carbon In water at 100℃; under 13501.4 Torr; for 3h; |
2-amino-4-(trifluoromethyl)pyridine
2-amino-4-trifluoromethylpyridine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In toluene at 10 - 20℃; | 96.6% |
2-amino-4-(trifluoromethyl)pyridine
2-amino-5-bromo-4-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With N-Bromosuccinimide In dichloromethane at 25℃; for 2h; Darkness; | 94% |
With N-Bromosuccinimide In tetrahydrofuran at 0 - 20℃; for 1h; Concentration; | 91% |
With N-Bromosuccinimide In dichloromethane at 20℃; Darkness; | 87.96% |
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