Products Categories
CAS No.: | 107-44-8 |
---|---|
Name: | Sarin. |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C4H10FO2P |
Molecular Weight: | 140.094 |
Synonyms: | Sarin.;SARINTYPEII;O-ISOPROPYLMETHYLPHOSPHONOFLUORIDATE;AGENTGB;SARIN-I;ISOPROPYLMETHYLPHOSPHONOFLUORIDATE;SARINTYPEI;SARIN-II |
Density: | 1.07g/cm3 |
Melting Point: | -56 C |
Boiling Point: | 147°Cat760mmHg |
Flash Point: | 42.7°C |
Appearance: | liquid |
Hazard Symbols: | Toxic by inhalation and skin absorption, cholinesterase inhibitor. |
Safety: | A deadly human poison by skin contact and inhalation. (A small drop on the skin can kill a man.) A deadly experimental poison by ingestion, inhalation, skin contact, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Human systemic effects: muscle weakness, bronchiolar constriction, nausea or vomiting, flaccid paralysis without anesthesia, miosis (pupillary constriction), cholinesterase inhibition. A “nerve gas” used as a chemical warfare agent. To fight fire, use foam, CO2, dry chemical. When heated to decomposition or reacted with steam, it emits very toxic fumes of F− and POx. See also PARATHION. |
PSA: | 36.11000 |
LogP: | 2.20380 |
IUPAC Name: 2-[Fluoro(methyl)phosphoryl]oxypropane
Synonyms of Isopropyl methanefluorophosphonate (CAS NO.107-44-8) : Phosphonofluoridic acid, P-methyl-, 1-methylethyl ester ; Propan-2-yl methylphosphonofluoridate ; (+-)-Isopropyl methylphosphonofluoridate ; 1-Methylethyl (+-)-methylphosphonofluoridate
CAS NO:107-44-8
Molecular Formula:C4H10FO2P
Molecular Weight :140.0932
Molecular Structure :
Index of Refraction:1.366
Surface Tension: 24 dyne/cm
Density: 1.07 g/cm3
Flash Point: 42.7 °C
Enthalpy of Vaporization: 36.82 kJ/mol
Boiling Point: 147 °C at 760 mmHg
Vapour Pressure: 5.71 mmHg at 25°C
Stability: Stability
Appearance: Isopropyl methanefluorophosphonate (CAS NO.107-44-8) is a colorless, odorless liquid.
Isopropyl methanefluorophosphonate (CAS NO.107-44-8) is used as a quick-acting military chemical nerve agent and chemical warfare agent.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | intravenous | 22ug/kg (0.022mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 50, 1961. | |
cat | LD50 | subcutaneous | 30ug/kg (0.03mg/kg) | Toxicology and Applied Pharmacology. Vol. 91, Pg. 55, 1987. | |
chicken | LD50 | subcutaneous | 16673ug/kg (16.673mg/kg) | Archives of Toxicology. Vol. 52, Pg. 71, 1983. | |
dog | LD50 | intravenous | 19ug/kg (0.019mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 50, 1961. | |
guinea pig | LC50 | inhalation | 128mg/m3/2M (128mg/m3) | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1126, 1986. | |
guinea pig | LD50 | subcutaneous | 30ug/kg (0.03mg/kg) | Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968. | |
hamster | LD50 | subcutaneous | 95ug/kg (0.095mg/kg) | Canadian Journal of Physiology and Pharmacology. Vol. 46, Pg. 109, 1968. | |
human | LD50 | skin | 28mg/kg (28mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Science Journal. Vol. 3(4), Pg. 33, 1967. |
human | TDLo | oral | 2ug/kg (0.002mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958. |
man | LDLo | intramuscular | 30ug/kg (0.03mg/kg) | Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958. | |
man | TCLo | inhalation | 90ug/m3 (0.09mg/m3) | SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE | Archives of Toxicology. Vol. 56, Pg. 201, 1985. Link to PubMed |
man | TDLo | oral | 102ug/kg/3D-I (0.102mg/kg) | BLOOD: OTHER CHANGES | Journal of Clinical Investigation. Vol. 37, Pg. 350, 1958. |
monkey | LD50 | intramuscular | 22300ng/kg (0.0223mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Fundamental and Applied Toxicology. Vol. 5, Pg. S169, 1985. |
monkey | LD50 | intravenous | 20ug/kg (0.02mg/kg) | Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000. | |
mouse | LC50 | inhalation | 5mg/m3/30M (5mg/m3) | Deutsche Gesundheitswesen. Vol. 15, Pg. 2179, 1960. | |
mouse | LD50 | intramuscular | 164ug/kg (0.164mg/kg) | Journal of Medicinal Chemistry. Vol. 31, Pg. 807, 1988. | |
mouse | LD50 | intraperitoneal | 283ug/kg (0.283mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 172, Pg. 62, 1968. | |
mouse | LD50 | intravenous | 109ug/kg (0.109mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES KIDNEY, URETER, AND BLADDER: INCONTINENCE | Journal of Toxicology and Environmental Health. Vol. 26, Pg. 437, 1989. |
mouse | LD50 | skin | 1080ug/kg (1.08mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | National Technical Information Service. Vol. PB158-508, |
mouse | LD50 | subcutaneous | 60ug/kg (0.06mg/kg) | Deutsche Gesundheitswesen. Vol. 15, Pg. 2179, 1960. | |
pig | LD50 | intravenous | 15ug/kg (0.015mg/kg) | Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000. | |
pig | LD50 | skin | 116mg/kg (116mg/kg) | Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000. | |
rabbit | LD50 | intravenous | 15ug/kg (0.015mg/kg) | Journal of Medicinal and Pharmaceutical Chemistry. Vol. 3, Pg. 353, 1961. | |
rabbit | LD50 | skin | 925ug/kg (0.925mg/kg) | BEHAVIORAL: COMA
| National Technical Information Service. Vol. PB158-508, |
rabbit | LD50 | subcutaneous | 30ug/kg (0.03mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS | Toxicology and Applied Pharmacology. Vol. 40, Pg. 109, 1977. |
rat | LD50 | intramuscular | 108ug/kg (0.108mg/kg) | Fundamental and Applied Toxicology. Vol. 5, Pg. S84, 1985. | |
rat | LD50 | intraperitoneal | 218ug/kg (0.218mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 139, Pg. 390, 1963. | |
rat | LD50 | intravenous | 39ug/kg (0.039mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 139, Pg. 390, 1963. | |
rat | LD50 | oral | 550ug/kg (0.55mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | National Technical Information Service. Vol. PB158-508, |
rat | LD50 | skin | 2500ug/kg (2.5mg/kg) | Journal of Toxicology and Environmental Health, Part A. Vol. 59, Pg. 387, 2000. | |
rat | LD50 | subcutaneous | 103ug/kg (0.103mg/kg) | British Journal of Pharmacology. Vol. 39, Pg. 822, 1970. |
EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.
A deadly human poison by skin contact and inhalation. (A small drop on the skin can kill a man.) A deadly experimental poison by ingestion, inhalation, skin contact, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Human systemic effects: muscle weakness, bronchiolar constriction, nausea or vomiting, flaccid paralysis without anesthesia, miosis (pupillary constriction), cholinesterase inhibition. A “nerve gas” used as a chemical warfare agent. To fight fire, use foam, CO2, dry chemical. When heated to decomposition or reacted with steam, it emits very toxic fumes of F− and POx. See also PARATHION.
RIDADR 2810
HazardClass 6.1(a)
PackingGroup I
1.Air & Water Reactions: Hydrolyzed by water, rapidly hydrolyzed by dilute aqueous sodium hydroxide. Water alone removes Fluoride atom producing nontoxic acid .
2.Reactivity Profile: Acidic conditions produce hydrogen fluoride; alkaline conditions produce isopropyl alcohol and polymers. When heated to decomposition or reacted with steam, Sarin. emits very toxic fumes of fluorides and oxides of phosphorus. Slightly corrosive to steel. Hydrolyzed by water
3.Health Hazard :Extremely toxic; lethal dose in humans may be as low as 0.01 mg/kg. Extremely active cholinesterase inhibitor. Toxic effects similar to, but more severe than those of parathion. Death within 15 minutes after fatal dose is absorbed.
4.Fire Hazard: Non-flammable. Acidic conditions produce hydrogen fluoride; alkaline conditions produce isopropyl alcohol and polymers. When heated to decomposition or reacted with steam, Sarin. emits very toxic fumes of fluorides and oxides of phosphorus. Slightly corrosive to steel. Hydrolyzed by water.