Reference

Determination of meclizine hydrochloride by ion-pair extraction with methyl orange

Determination of meclizine hydrochloride by ion-pair extraction with methyl orange. Hom, F. S.; Ebert, W. R. (Res. Dev. Dep., R. P. Scherer Corp., Detroit, Mich., USA). J. Pharm. Sci., 66(5), 710-13 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) A method, based on ion-pair extn., is described for the quantification of meclizine-2HCl (I) [1104-22-9] in various pharmaceutical dosage forms, for content uniformity detn., and for concn. monitoring in dissoln. and bioavailability studies. Me orange, dissolved in pH 2.8 MacIlvaine buffer, gave excellent recovery of meclizine after its isolation from aq. solns. of gelatin, urine, and blood serum. The CHCl3-extd. mol. species appeared to be a 1:1 ion-pair. Beer's law was obeyed for a wide concn. range. Because the extd. species seemed well defined and stable and since a surface or an interphase adsorption phenomenon was not a problem, the reported method is considered sensitive, accurate, precise, rapid, and simple.

Antivertigo preparations containing stevia for masking offensive taste

Antivertigo preparations containing stevia for masking offensive taste. Kitajima, Hideaki; Okudaira, Ichiro; Tsunoda, Kenji (Taisho Pharma Co Ltd, Japan). Jpn. Kokai Tokkyo Koho JP 09020653 A2 21 Jan 1997 Heisei, 5 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: A61K031-135. ICS: A61K031-44; A61K031-445; A61K031-495; A61K047-26. APPLICATION: JP 1996-94342 16 Apr 1996. PRIORITY: JP 1995-108502 2 May 1995. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) The antivertigo prepns. contain 31 selected from meclizine hydrochloride (I), diphenidol hydrochloride, diphenhydramine hydrochloride, and chlorpheniramine maleate and stevia. Addn. of stevia to a liq.There are some commonly used reagents with their cas registry numbers 147-24-0 and 1104-22-9 in this article. contg. I, diprophylline, D-sorbitol soln., benzoic acid, Na citrate, polyoxyethylene hydrogenated castor oil, and H2O improved the taste. .