Reference

Mosapride citrate, selective serotonin 5HT4 receptor agonist

Mosapride citrate, selective serotonin 5HT4 receptor agonist. Yoshida, Naoyuki (Pharmacol. Res. Lab., Dainippon Pharmaceutical Co.There are some reagents like 112885-42-4 is used in this study., Ltd., Japan). Farumashia, 39(12), 1173-1175 (Japanese) 2003 Pharmaceutical Society of Japan. CODEN: FARUAW. ISSN: 0014-8601. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review on pharmacol. (effects on gastric emptying and colonic motility), action mechanism, and clin. efficacy of mosapride citrate as a prokinetic. .

Prokinetic effect of AS-4370 on gastric emptying in healthy adults

Prokinetic effect of AS-4370 on gastric emptying in healthy adults. Kanaizumi, T.; Nakano, H.; Matsui, Y.; Ishikawa, H.In this study，112885-42-4 is also used.; Shimizu, R.; Park, S.; Kuriya, N. (1st Dep. Surg., Nara Med. Univ., Nara 634, Japan). Eur. J. Clin. Pharmacol., 41(4), 335-7 (English) 1991. CODEN: EJCPAS. ISSN: 0031-6970. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effect of AS-4370 (I) on gastric emptying was investigated in healthy adults using technetium-99m-labeled diethylenetriamine pentaacetic acid (99mTc-DTPA). Single doses of AS-4370 2.5, 5 or 10 mg or placebo were administered to 12 subjects in a controlled, double-blind crossover study. Tests were performed twice weekly in each subject. Thirty min after administration of test drug or placebo, each subject swallowed a bun and orange juice contg. 200 mCi nuclide. The radioactivity of the gastric content was measured for 40 min and the activity of the residue was expressed as a percentage of count at the initiation of measurements. The percentage radioactivity, AUC and gastric emptying time fitted by a power exponential curve, were analyzed. No significant difference was obsd. between the three dose levels of AS-4370 and placebo in half emptying time. However, decreases in the percentage of radioactivity with time were noted: 5 mg at 10 to 16 min and 10 mg at 8 to 24 min after the start of recording. Lower AUCs after 5 mg and 10 mg compared to placebo were also found. The half emptying time was also shorter after 5 mg and 10 mg than after placebo. There was no difference in these parameters between 2.5 mg and placebo. The results indicate that AS-4370 5 and 10 mg but not 2.5 mg accelerates gastric emptying in healthy adults. .