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113919-36-1

Basic Information
CAS No.: 113919-36-1
Name: 2-(PHOSPHONOMETHYL)-PENTANEDIOIC ACID
Article Data: 1
Molecular Structure:
Molecular Structure of 113919-36-1 (2-(PHOSPHONOMETHYL)-PENTANEDIOIC ACID)
Formula: C6H13 N2 O5 P
Molecular Weight: 224.153
Synonyms: 4-(PHOSPHONOMETHYL)-2-PIPERAZINECARBOXYLIC ACID;2-(PHOSPHONOMETHYL)-PENTANEDIOIC ACID;2-PHOSPHONOMETHYL-PENTANEDOIC ACID;PMPA;PMPA(NMDAantagonist)
PSA: 119.91000
LogP: -1.25330
Synthetic route

4-(Diethoxy-phosphorylmethyl)-piperazine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

113919-36-1

4-Phosphonomethyl-piperazine-2-carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride 1.) reflux, 24 h, 2.) 25 deg C, 3.5 d;86%
126937-44-8

2-methyl 1-phenylmethyl 1,2-piperazinedicarboxilate, trifluoroacetate

113919-36-1

4-Phosphonomethyl-piperazine-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 41 percent / K2CO3 / acetonitrile / 1.) reflux, 4 h, 2.) 25 deg C, 2.5 d
2: 86 percent / 6 M aq. HCl / 1.) reflux, 24 h, 2.) 25 deg C, 3.5 d
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