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CAS No.: | 120118-14-1 |
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Name: | 4-Chlor-2-cyano-5-(4-methylphenyl)imidazol |
Article Data: | 5 |
Molecular Structure: | |
Formula: | C11H8 Cl N3 |
Molecular Weight: | 217.658 |
Synonyms: | 1H-Imidazole-2-carbonitrile,4-chloro-5-(4-methylphenyl)- (9CI); CCIM |
Density: | 1.362g/cm3 |
Boiling Point: | 410.891°C at 760 mmHg |
Flash Point: | 202.3°C |
PSA: | 52.47000 |
LogP: | 2.91018 |
5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
Conditions | Yield |
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With thionyl chloride In ethyl acetate for 3h; Reflux; | 75% |
5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
Conditions | Yield |
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Multi-step reaction with 4 steps 1: thionyl chloride / 5 h / 85 °C / Cooling with ice 2: ammonia / methanol / 36 h / 0 °C 3: thionyl chloride / 12 h / 85 °C 4: N-chloro-succinimide / acetonitrile / 3 h / 25 °C View Scheme |
5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ammonia / methanol / 36 h / 0 °C 2: thionyl chloride / 12 h / 85 °C 3: N-chloro-succinimide / acetonitrile / 3 h / 25 °C View Scheme |
5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: thionyl chloride / 12 h / 85 °C 2: N-chloro-succinimide / acetonitrile / 3 h / 25 °C View Scheme |
5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
Conditions | Yield |
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With N-chloro-succinimide In acetonitrile at 25℃; for 3h; Time; | 0.18 g |
With sulfuryl dichloride In N,N-dimethyl acetamide; acetonitrile at 20 - 25℃; | 104 g |
para-methylacetophenone
5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
Conditions | Yield |
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Multi-step reaction with 3 steps 1: selenium(IV) oxide / 1,4-dioxane; water / 5 h / 50 - 110 °C 2: hydroxylamine hydrochloride / water; methanol / 2 h / Reflux 3: thionyl chloride / ethyl acetate / 3 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: dihydrogen peroxide; bromine / cyclohexane / 4 h / 20 °C 2.1: dimethyl sulfoxide / 4 h / 120 °C 3.1: hydroxylamine sulfate / methanol / 6 h / Reflux 4.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 25 °C 4.2: 3 h / 25 °C / Cooling with ice View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; bromine / 7 h / 42 °C 2.1: hydroxylamine / methanol / 12 h / 50 °C 3.1: ammonia / methanol / 32 h / 0 °C 3.2: 10 h / 88 °C 3.3: 2.5 h / 28 °C View Scheme |
4-methylphenylglyoxal
5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
Conditions | Yield |
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Multi-step reaction with 2 steps 1: hydroxylamine hydrochloride / water; methanol / 2 h / Reflux 2: thionyl chloride / ethyl acetate / 3 h / Reflux View Scheme |
4-(bromoacetyl)toluene
5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dimethyl sulfoxide / 4 h / 120 °C 2.1: hydroxylamine sulfate / methanol / 6 h / Reflux 3.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 25 °C 3.2: 3 h / 25 °C / Cooling with ice View Scheme |
5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
Conditions | Yield |
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Stage #1: C11H11N3O3 With thionyl chloride In N,N-dimethyl-formamide at 25℃; for 3h; Stage #2: With sulfur dichloride at 25℃; for 3h; Cooling with ice; |
2,2-dibromo-1-(4-methylphenyl)ethanone
5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile
Conditions | Yield |
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Multi-step reaction with 2 steps 1.1: hydroxylamine / methanol / 12 h / 50 °C 2.1: ammonia / methanol / 32 h / 0 °C 2.2: 10 h / 88 °C 2.3: 2.5 h / 28 °C View Scheme |