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Cas Database |
| Name |
Sodium aurothiomalate |
EINECS | 235-479-7 |
| CAS No. | 12244-57-4 | Density | N/A |
| PSA | 105.56000 | LogP | -2.56010 |
| Solubility | Very soluble in water. Practically insoluble in alcohol, ether | Melting Point |
N/A |
| Formula | C4H6 O4 S . Au . x Na | Boiling Point | N/A |
| Molecular Weight | 368.096 | Flash Point | N/A |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by subcutaneous and intramuscular routes. Moderately toxic by intravenous route. Human systemic effects: aggression, agranulocytosis, aplastic anemia, cell count changes, changes in circulation, cholestatic jaundice, dermatitis, encephalitis, fasciculations, flaccid paralysis without anesthesia, hemorrhage, hepatitis (hepatocellular necrosis), increased body temperature, interstitial fibrosis, muscle weakness, proteinuria, recording from peripheral motor nerve, depressed renal function tests, somnolence, structural changes in nerve sheath, thrombocytopenia, uncharacterized allergic reaction, changes in blood, teeth, and supporting structures. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic Na2O and SOx. | Risk Codes | R20/21/22;R43 |
| Molecular Structure |
|
Hazard Symbols |
|
| Synonyms |
Butanedioicacid, mercapto-, monogold(1+) sodium salt (9CI);Aurolate;Aurothiomalate sodium;Chrysothios;Gold sodium thiomalate;Kidon;Miocrisina;Myochrysin;Myochrysine;Myocrisin;Shiosol;Sodium aurithiomalate;Sodium aurothiomalate;Tauredon; |
Article Data | 1 |
Sodium aurothiomalate Chemical Properties
IUPAC Name: Disodium; gold(1+); 2-sulfidobutanedioate
CAS: 12244-57-4
Formula: C4H3AuNa2O4S
Molecular Weight: 390.08
The Molecular Structure of Disodium; gold(1+); 2-sulfidobutanedioate (CAS NO.12244-57-4):
Flash Point: 108.8 °C
Enthalpy of Vaporization: 54.37 kJ/mol
Boiling Point: 256.3 °C at 760 mmHg
Vapour Pressure: 0.00475 mmHg at 25°C
Product Categories: organic-metal salt.
Sodium aurothiomalate Toxicity Data With Reference
| 1. | orl-man TDLo:5500 µg/kg:PNS,KID,BLD | ARHEAW Arthritis and Rheumatism. 19 (1976),936. | ||
| 2. | ims-wmn TDLo:182 µg/kg:SKN | BMJOAE British Medical Journal. 2 (1976),1294. | ||
| 3. | ivn-wmn TDLo:2700 µg/kg/4W-I:CNS | JRHUA9 Journal of Rheumatology. 11 (1984),235. | ||
| 4. | ims-wmn TDLo:20 mg/kg/1Y:CNS,KID | ARPAAQ Archives of Pathology. 96 (1973),133. | ||
| 5. | ims-man TDLo:5 mg/kg/13W:BLD,MSK | JAMAAP JAMA, Journal of the American Medical Association. 133 (1947),754. | ||
| 6. | ims-wmn LDLo:600 µg/kg/1W-I:PUL,SYS | JRSMD9 Journal of the Royal Society of Medicine. 77 (1984),960. | ||
| 7. | par-wmn TDLo:3366 µg/kg/2W:CNS,PNS | NEURAI Neurology. 20 (1970),455. | ||
| 8. | par-man TDLo:12,500 µg/kg/7W-I:CNS,PNS | JRHUA9 Journal of Rheumatology. 11 (1984),233. | ||
| 9. | par-man TDLo:7857 µg/kg/11W-I:SKN | BMJOAE British Medical Journal. 286 (1983),1547. | ||
| 10. | unr-cld TDLo:11,900 µg/kg/18W-I: | JRHUA9 Journal of Rheumatology. 13 (1986),224. | ||
Sodium aurothiomalate Safety Profile
Poison by subcutaneous and intramuscular routes. Moderately toxic by intravenous route. Human systemic effects: aggression, agranulocytosis, aplastic anemia, cell count changes, changes in circulation, cholestatic jaundice, dermatitis, encephalitis, fasciculations, flaccid paralysis without anesthesia, hemorrhage, hepatitis (hepatocellular necrosis), increased body temperature, interstitial fibrosis, muscle weakness, proteinuria, recording from peripheral motor nerve, depressed renal function tests, somnolence, structural changes in nerve sheath, thrombocytopenia, uncharacterized allergic reaction, changes in blood, teeth, and supporting structures. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic Na2O and SOx.
Safety Information about Disodium; gold(1+); 2-sulfidobutanedioate (CAS NO.12244-57-4):
Hazard Codes:
Xn: 
Risk Statements about Disodium; gold(1+); 2-sulfidobutanedioate (CAS NO.12244-57-4):
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R43: May cause sensitization by skin contact.
Safety Statements about Disodium; gold(1+); 2-sulfidobutanedioate (CAS NO.12244-57-4):
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: MD5435000
Sodium aurothiomalate Specification
Disodium ; gold(1+) ; 2-sulfidobutanedioate with CAS number of 12244-57-4 is also known as ((1,2-Dicarboxyethyl)thio)golddisodiumsalt ; ((1,2-Dicarboxyethyl)thio)-goldisodiumsalt ; (dihydrogenmercaptosuccinato)golddisodiumsalt ; (Mercaptobutanedioato(1-))golddisodiumsalt ; Aurothiomaleatesodium ; Autm ; chrysothios ; disodiumaurothiomalate . It can be used for anti-inflammatory analgesic .
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