Reference

Quantitative determination of sodium usnate in dosage forms

Quantitative determination of sodium usnate in dosage forms. Morozova, O. V.; Dargaeva, T. D.; Brutko, L. I. (Vses.-Nauchno-Issled. Inst. Farm., Moscow, USSR). Farmatsiya (Moscow), 33(6), 30-3 (Russian) 1984. CODEN: FRMTAL. ISSN: 0367-3014. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Na usnate (I) [34769-44-3] was detd. in pharmaceuticals by a spectrophotometric method base on hydrolysis of I to usnic acid (II) [125-46-2] and measurement of the absorbance of II at 285 nm. The relative error was ￡2% and the recovery was 99.1-100.5%. A calibration curve was constructed by using std. II. The sensitivity of the detn. was 1 mg/mL.

Mutagenicity of lichen constituents

Mutagenicity of lichen constituents. Shibamoto, T.; Wei, C. I. (Dep. Environ. Toxicol., Univ. California, Davis, CA, USA). Environ. Mutagen., 6(5), 757-62 (English) 1984. CODEN: ENMUDM. ISSN: 0192-2521. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Usnic acid (I) [125-46-2] (the most abundant lichen constituent), physodic acid [84-24-2], and physodalic acid (II) [90689-60-4], isolated from Hypogymnia enteromorph, were tested for mutagenicity in the Ames Salmonella microsome assay. II exhibited clear dose-related mutagenicity against S. typhimurium strain TA 100 with or without S9 mix in plate-incorporation and preincubation assays. The addn. of S9 mix increased the no. of revertants ~3- and 4-fold in preincubation and plate-incorporation assays, resp.