Reference

Diffusion of orally administered antibiotics into suction skin blister in man

Diffusion of orally administered antibiotics into suction skin blister in man. Magliulo, E.; Torre, D.; Bianchi, P. P.; Martinenghi, P.; Maggiolo, F.; Maggiolo, M.; Martina, A. (Div. Infect. Dis., Reg. Hosp., Varese 21100, Italy). Chemioterapia, 2(6), 404-9 (English) 1983. CODEN: CHEMEV. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 10 Single oral doses of ampicillin [69-53-4], azidocillin [17243-38-8], and erythromycin Et succinate [1264-62-6] (analogous to those usually employed in general practice) were given to healthy subjects and the penetration of the antibiotics in extravascular fluid was measured by the suction-skin-blister (SSB) technique.There are some commonly used reagents with their cas registry numbers 69-53-4 and 17243-38-8 in this article. Concns. in SSB fluid appeared adequate for treatment of most community-acquired infections, as assessed by the ratio of antibiotic levels to the range of min. inhibitory concns. Therapy with the 2 b-lactam antibiotics seems more appropriate than with erythromycin, whereas azidocillin is apparently more effective than ampicillin against Streptococcus pneumoniae and S. pyogenes. .

Effects of macrolide antibiotics on barbiturate sleeping time in mice

Effects of macrolide antibiotics on barbiturate sleeping time in mice.Some chemicals with cas registry numbers like 76-74-4 and 8025-81-8 are also used. Descotes, J.; Evreux, J. Cl. (Lab. Pharmacol., Fac. Med. Alexis Carrel, Lyon F-69008, Fr.). Experientia, 39(12), 1389-90 (English) 1983. CODEN: EXPEAM. ISSN: 0014-4754. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Triacetyloleandomycin [2751-09-9] and josamycin [16846-24-5], when administered to inbred Balb/c mice orally twice daily at a dose of 12.5 or 25 mg/kg over 3 days, increased barbiturate sleeping time significantly. In contrast, erythromycin ethylsuccinate [1264-62-6], erythromycin propionate [134-36-1], midecamycin [35457-80-8], and spiramycin [8025-81-8] were devoid of any such activity under the same conditions. The relationship of these results to the effect of macrolide antibiotics on drug-metabolizing enzymes and their drug-drug interactions are discussed. .