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CAS No.: | 131347-76-7 |
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Name: | (R)-3-Aminopentanoic acid |
Article Data: | 7 |
Molecular Structure: | |
Formula: | C5H11NO2 |
Molecular Weight: | 117.148 |
Synonyms: | Pentanoicacid, 3-amino-, (R)-;(-)-3-Aminopentanoic acid; |
Density: | 1.067 g/cm3 |
Boiling Point: | 230.142 °C at 760 mmHg |
Flash Point: | 92.987 °C |
Appearance: | Colorless to pale yellow liquid |
PSA: | 63.32000 |
LogP: | 0.89870 |
(R)-3-N,N-dibenzylaminopentanoic acid
(R)-β-aminopentanoic acid
Conditions | Yield |
---|---|
With hydrogen; palladium dihydroxide In methanol for 3h; Ambient temperature; | 95% |
With hydrogen; palladium dihydroxide In methanol for 3h; Ambient temperature; | 95% |
tert-butyl (R)-3-aminopentanoate
(R)-β-aminopentanoic acid
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 20℃; for 2h; | 89% |
(3R)-3-(tosylamino)pentanoic acid
(R)-β-aminopentanoic acid
Conditions | Yield |
---|---|
With hydrogen bromide; methyloxirane; phenol 1) reflux, 4 h; Yield given. Multistep reaction; | |
With hydrogen bromide; methyloxirane 1.) phenol, reflux, 4 h, 2.) EtOH, reflux, 2 h; Yield given. Multistep reaction; |
Methyl (E)-2-pentenoate
A
(R)-β-aminopentanoic acid
B
(3S)-3-aminopentanoic acid
Conditions | Yield |
---|---|
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; |
(R)-β-aminopentanoic acid
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethanol at 20℃; under 3800 Torr; |
tert-butyl (3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)pentanoate
(R)-β-aminopentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 95 percent / H2 / Pd/C / methanol / 50 °C / 3800 Torr 2: 89 percent / TFA / CH2Cl2 / 2 h / 20 °C View Scheme |
(2E)-2-pentenoic acid tert-butyl ester
(R)-β-aminopentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 92 percent / n-BuLi / tetrahydrofuran; hexane / -78 °C 2: 95 percent / H2 / Pd/C / methanol / 50 °C / 3800 Torr 3: 89 percent / TFA / CH2Cl2 / 2 h / 20 °C View Scheme |
benzyl (E)-pent-2-enoate
(R)-β-aminopentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 67 percent / n-BuLi / tetrahydrofuran; hexane / -78 °C 2: H2 / Pd/C / ethanol / 20 °C / 3800 Torr View Scheme |
(3R)-ethyl 3-(tosylamino)pentanoate
(R)-β-aminopentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 93 percent / K2CO3 / methanol; H2O / 24 h / Ambient temperature 2: 1.) 47percent aq. HBr, 2.) methyloxirane / 1.) phenol, reflux, 4 h, 2.) EtOH, reflux, 2 h View Scheme | |
Multi-step reaction with 2 steps 1: 93 percent / K2CO3 / methanol; H2O / 24 h / 25 °C 2: 1) PhOH, 47percent aq. HBr, 2) epoxypropane / 1) reflux, 4 h View Scheme |
(R)-3-N,N-dibenzylaminopentanenitrile
(R)-β-aminopentanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 91 percent / conc. aq. HCl / 3 h / 80 °C 2: 95 percent / H2 / 20percent Pd(OH)2/C / methanol / 3 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: 90 percent / conc. aq. HCl / 3 h / Heating 2: 95 percent / H2 / Pd(OH)2/C / methanol / 3 h / Ambient temperature View Scheme |