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CAS No.: | 13283-91-5 |
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Name: | 3-ketooctanoic acid |
Article Data: | 15 |
Molecular Structure: | |
Formula: | C8H14 O3 |
Molecular Weight: | 158.197 |
Synonyms: | Caprylicacid, b-oxo- (4CI); 3-Ketooctanoic acid;3-Oxocaprylic acid; 3-Oxooctanoic acid; b-Ketooctanoic acid; b-Oxooctanoic acid |
Density: | 1.038g/cm3 |
Boiling Point: | 275.6°Cat760mmHg |
Flash Point: | 134.7°C |
PSA: | 54.37000 |
LogP: | 1.61050 |
benzyl 3-oxooctanoate
3-oxooctanoic acid
Conditions | Yield |
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With palladium 10% on activated carbon; hydrogen In methanol under 2585.81 Torr; for 8h; | 99% |
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 20℃; under 760.051 Torr; for 1h; Inert atmosphere; | 95% |
Conditions | Yield |
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Stage #1: bis(trimethylsilyl) malonate With n-butyllithium In diethyl ether at -78 - -10℃; Stage #2: Hexanoyl chloride In diethyl ether at -10℃; for 0.5h; | 87% |
(i) nBuLi, (ii) /BRN= 506332/, (iii) aq. H2SO4; Multistep reaction; |
Hexanoyl chloride
3-oxooctanoic acid
Conditions | Yield |
---|---|
Stage #1: bis(trimethylsilyl) malonate With n-butyllithium In diethyl ether at -78 - -10℃; Stage #2: Hexanoyl chloride In diethyl ether at -10℃; for 0.5h; | 87% |
methyl 3-oxooctanoate
3-oxooctanoic acid
Conditions | Yield |
---|---|
With water; sodium methylate In methanol at 20℃; for 18h; | 50% |
With hydrogenchloride; acetic acid anschliessendes Erhitzen mit wss. Salzsaeure; | |
With potassium hydroxide In ethanol; water for 6h; Ambient temperature; Yield given; | |
hydrolysis; |
oct-2-ynoic acid
3-oxooctanoic acid
Conditions | Yield |
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With potassium hydroxide |
methyl 2-octynoate
3-oxooctanoic acid
Conditions | Yield |
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With potassium hydroxide; ethanol |
ethyl 3-oxooctanoate
3-oxooctanoic acid
Conditions | Yield |
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With potassium hydroxide Verseifung; | |
With hydroxide; hydrogen cation | |
With potassium hydroxide Yield given; |
Conditions | Yield |
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In N,N-dimethyl-formamide at 120℃; for 24h; |
ethyl β-hydroxyoctanoate
3-oxooctanoic acid
Conditions | Yield |
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Multi-step reaction with 2 steps 1: Jones oxidation 2: KOH View Scheme |