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Detail of "132907-72-3"

  • CAS Number:
  • 132907-72-3
  • Name:

  • Methanone,(1-methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]-,hydrochloride (1:1)

  • Superlist Name:
  • Ramosetron hydrochloride
  • Molecular Structure:
  • Formula:
  • C17H18ClN3O
  • Molecular Weight:
  • 315.79732
  • Synonyms:
  • Methanone,(1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-,monohydrochloride, (R)-;Methanone,(1-methyl-1H-indol-3-yl)[(5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl]-,monohydrochloride (9CI);(-)-(R)-5-[(1-Methyl-1H-indol-3-yl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazolemonohydrochloride;(R)-(-)-Ramosetron hydrochloride;Irribow;Ramosetronhydrochloride;YM 060;
  • Boiling Point:
  • 579.7 °C at 760 mmHg
  • Flash Point:
  • 304.4 °C
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Reference

New antiemetic ramosetron hydrochloride
New antiemetic ramosetron hydrochloride. Tsukagoshi, Shigeru (Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Japan). Gan to Kagaku Ryoho, 24(3), 371-380 (Japanese) 1997 Gan to Kagaku Ryohosha. CODEN: GTKRDX. ISSN: 0385-0684. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Ramosetron hydrochloride is a 5-HT3 receptor antagonist-type antiemetic, which was developed in Japan. It has an indole ring which is the mother nucleus of serotonin (5-HT) and a tetrahydrobenzimidazole radical. These components are linked by a carbonyl radical. It was reported in non-clin. studies that ramosetron hydrochloride exhibited more potent and sustained antagonistic activities against 5-HT3 receptors than existing 5-HT3 receptor antagonist-type antiemetics. It was also reported that ramosetron hdyrochloride inhibited vomiting by anticancer drugs in a potent and sustained manner. The phase I trial was initiated in May, 1991. Phase II and phase III trials were then conducted in a total of 357 patients at 121 institutions in Japan. The symptoms targeted in these trials were nausea and vomiting induced by anticancer drugs, such as cisplatin.In this article, certain chemicals are used. One of their cas registry numbers is 132907-72-3 Based on the results of the phase II trial, it was recommended that ramosetron hydrochloride be injected once daily at a dose of 0.3 mg. In phase III trial, a placebo-controlled double-blind study and an open trial were performed. The utility of the drug seemed to be confirmed by the results of these studies. Ramosetron hydrochloride showed an efficacy rate of 79.8% (178/223 patients) against nausea and vomiting induced by anticancer drugs, such as cisplatin when administered at a dose of 0.3 mg. The efficacy rate was 85.1% (40/47 patients) when given at a dose of 0.3mg before the administration of anticancer drugs, such as cisplatin. The incidence of adverse effects was 2.0% (7/352 patients). Main adverse effects reported were feeling of heat, headache, and heavy feeling in the head. These adverse effects were of no clin. importance. .
Usefulness of 5-HT3 receptor antagonists in irritable bowel syndrome - pharmacological profile of ramosetron hydrochloride
Usefulness of 5-HT3 receptor antagonists in irritable bowel syndrome - pharmacological profile of ramosetron hydrochloride. Hirata, Takuya; Sasamata, Masao; Miyata, Keiji (Pharmacology Lab., Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., Tsukuba 305-8585, Japan). Saibo, 35(10), 398-401 (Japanese) 2003 Nyu Saiensusha. CODEN: SAIBC7. ISSN: 1346-7557. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review, discussing the usefulness of 5-HT receptor antagonists in irritable bowel syndrome and pharmacol. profile of ramosetron hydrochloride.Except for chemicals metioned above, 132907-72-3 is also used. .
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