Reference

Androgen receptor-mediated inhibition of estrogen-induced uterine peroxidase

Androgen receptor-mediated inhibition of estrogen-induced uterine peroxidase.Some chemicals with cas registry numbers like 9003-99-0 and 9001-40-5 are also used. Jellinck, Peter H.; Newcombe, Anne Marie (Dep. Biochem., Queen's Univ., Kingston, ON K7L 3N6, Can.). J. Steroid Biochem., 19(6), 1713-17 (English) 1983. CODEN: JSTBBK. ISSN: 0022-4731. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Flutamide [13311-84-7], an anti-androgen known to act through the androgen receptor, abolished the inhibitory action of testosterone [58-22-0] on the induction of peroxidase (EC 1.11.1.7) [9003-99-0] in immature rat uteri without affecting inhibition produced by progesterone [57-83-0]. The time course of the androgen effect on estrogen-induced uterine peroxidase, uterine wt., and glucose 6-phosphate dehydrogenase [9001-40-5] activity was also detd. together with the effect of flutamide on these steroid hormone-sensitive parameters. The possible mechanism of action of these compds. is discussed, particularly in the light of estrogen-induced eosinophilia. The obsd. interaction between testosterone and estradiol [50-28-2] is apparently mediated through their own specific receptors and not by illicit occupation of the estrogen by the androgen. 5-Androstene-3b,17b-diol [521-17-5], an androgen known to exert estrogenic effects through the estrogen receptor, induced uterine peroxidase and was without effect on the action of estradiol, in contrast to testosterone. .

Effects in mice of orchidectomy and flutamide on hypothalamic luteinizing hormone-releasing hormone, plasma luteinizing hormone, and seminal vesicle weights

Effects in mice of orchidectomy and flutamide on hypothalamic luteinizing hormone-releasing hormone, plasma luteinizing hormone, and seminal vesicle weights. 13311-84-7 and 58-22-0 are also in the experiment. Hegeman, Sally L.; Ho, Mei Shang; Bay, Mae; Beck, Lyle V. (Sch. Med., Indiana Univ., Bloomington, IN 47405, USA). Anterior Pituitary Gland, 287-93. Edited by: Bhatnagar, Ajay S. CNRS: Paris, Fr. (English) 1983. CODEN: 50SMAN. DOCUMENT TYPE: Conference CA Section: 2 (Mammalian Hormones) The hypothalamic content of LH-RH [9034-40-6] was decreased following orchidectomy and increased after testosterone [58-22-0] administration, and flutamide [13311-84-7] had peripheral antiandrogenic effects in mice similar to those previously reported for rats (i.e., the drug-induced marked shrinkage of seminal vesicles and increases in plasma LH [9002-67-9] levels). However, flutamide did not measurably alter the content of LH-H in the hypothalamuses of normal mice, orchidectomized mice, testosterone-treated mice, or mice subjected to both orchidectomy and testosterone treatment. Hence, flutamide apparently showed neither androgenic nor antiandrogenic effects on hypothalamic LH-RH-secreting neurons. Since orchidectomy resulted in inhibition rather than stimulation of LH-RH secretion, neg. feedback effects of androgens on LH secretion must occur primarily through direct inhibition of LH secretion rather than indirectly through inhibition of LH-RH secretion. The action of flutamide to stimulate increases in plasma LH levels presumably results mainly from its suppression of these feedback effects of endogenous androgens. .