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134-80-5

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Basic Information
CAS No.: 134-80-5
Name: Amfepramone hydrochloride
Molecular Structure:
Molecular Structure of 134-80-5 (Amfepramone hydrochloride)
Formula: C13H19 N O . Cl H
Molecular Weight: 241.761
Synonyms: 1-Propanone,2-(diethylamino)-1-phenyl-, hydrochloride (9CI); Propiophenone,2-(diethylamino)-, hydrochloride (6CI,8CI);1-Phenyl-2-(diethylamino)propanone-1 hydrochloride;2-(Diethylamino)propiophenone hydrochloride; Amfepramon hydrochloride;Amphepramonum hydrochloride; Anfamon; Anorex; Danylen; Diethylpropionhydrochloride; Diethylpropione hydrochloride; Dobesin; Fepranon; Frekentine;Keramik; Keramin; Moderatan; Modulor; Parabolin; Phepranon; Prefamone; Regenon;Regenon hydrochloride; Tenuate; Tenuate hydrochloride; Tenuate-Dospan; Tepanil;Tylinal; a-(Diethylamino)propiophenonehydrochloride; a-Benzoyltriethylaminehydrochloride; a-Benzoyltriethylammoniumchloride
EINECS: 205-156-5
Density: 0.972g/cm3
Melting Point: 180-1810C
Boiling Point: 292°Cat760mmHg
Flash Point: 95.4°C
Hazard Symbols: F,T
Risk Codes: 11-23/24/25-39/23/24/25-20/21/22
Safety: Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits very toxic fumes of HCl, NH3, and NOx.
PSA: 20.31000
LogP: 3.40160
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Chemistry

Chemistry informtion about 2-Diethylaminopropiophenone Hydrochloride (CAS NO.134-80-5) is:
IUPAC Name: 2-(Diethylamino)-1-Phenylpropan-1-One Hydrochloride
Synonyms: Diethylpropion Hydrochloride ; 2-(Diethylamino)Propiophenone Hydrochloride ; 1-Phenyl-2-Diethylamino-1-Propanonehydrochloride ; 1-Phenyl-2-Diethylaminopropanone-1hydrochloride ; 2-(Diethylamino)-1-Phenyl-1-Propanonhydrochloride ; 2-(Diethylamino)-Propiophenonhydrochloride ; Alpha-Benzoyltriethylaminehydrochloride ; Alpha-Benzoyltriethylammoniumchloride
Product Categories: Aromatics ; Intermediates & Fine Chemicals ; Pharmaceuticals 
MF: C13H20ClNO
MW: 241.76
EINECS: 205-156-5
Melting Point: 180-1810°C
Flash Point: 95.4 °C
Boiling Point: 292 °C at 760 mmHg
Vapour Pressure: 0.00189 mmHg at 25°C
Enthalpy of Vaporization: 53.14 kJ/mol
Following is the molecular structure of 2-Diethylaminopropiophenone Hydrochloride (CAS NO.134-80-5) is:

Uses

2-Diethylaminopropiophenone Hydrochloride (CAS NO.134-80-5) can be used to controlled substance (stimulant) and used as anorexic.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 160mg/kg (160mg/kg)   Therapie. Vol. 17, Pg. 373, 1962.
mouse LD50 intravenous 50mg/kg (50mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 17, Pg. 182, 1960.
mouse LD50 oral 385mg/kg (385mg/kg)   Therapie. Vol. 17, Pg. 373, 1962.
mouse LD50 subcutaneous 450mg/kg (450mg/kg) sense organs and special senses: mydriasis (pupillary dilation): eye behavioral: excitement skin and appendages (skin): hair: other Acta Pharmaceutica Suecica. Vol. 4, Pg. 37, 1967.
rat LD50 intraperitoneal 139mg/kg (139mg/kg) behavioral: excitement Acta Pharmacologica et Toxicologica. Vol. 17, Pg. 121, 1960.
rat LD50 oral 400mg/kg (400mg/kg)   Therapie. Vol. 17, Pg. 373, 1962.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits very toxic fumes of HCl, NH3, and NOx.

Specification

 2-Diethylaminopropiophenone Hydrochloride (CAS NO.134-80-5) is a off-white solid.