Detail of "13893-53-3"

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Effectiveness of sodium nitrite, amyl nitrite and sodium thiosulfate against acute ocular intoxication with AC 94,149 (2-amino-2,3-dimethylbutyronitrile) in albino rabbits

Effectiveness of sodium nitrite, amyl nitrite and sodium thiosulfate against acute ocular intoxication with AC 94,149 (2-amino-2,3-dimethylbutyronitrile) in albino rabbits. Johnson, M. C.; Fischer, J. E. (Agric. Res. Div., Am. Cyanamid Co., Princeton, NJ 08540, USA). Ann. N. Y. Acad. Sci., 435(Colloq. Biol. Sci., 1st, 1983), 283-5 (English) 1984. CODEN: ANYAA9. ISSN: 0077-8923. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Administration of AC 94149 (I) [13893-53-3] into the conjunctival sac of rabbits resulted in 100% mortality. Ocular administration of I followed by antidotal treatment with inhaled amyl nitrite [110-46-3] alone also resulted in 100% mortality. However, ocular administration of I followed by antidotal treatment with i.v. NaNO2 (10 mg/kg) resulted in 100% survival. In contrast, antidotal treatment with a combination of inhaled amyl nitrite followed by i.v. administration of NaNO2 (10 mg/kg) and Na thiosulfate (200 mg/kg) following I administration resulted in 33% mortality. All surviving animals, in both groups, showed no untoward effects throughout a 14-day observation period.

2-(4-Oxoimidazolin-2-yl)pyridine and -quinoline-3-carboxylic acid derivatives

2-(4-Oxoimidazolin-2-yl)pyridine and -quinoline-3-carboxylic acid derivatives. (Shell Internationale Research Maatschappij B. V., USA). Jpn. 4945-42-0 and 13893-53-3 are also occured in this study. Kokai Tokkyo Koho JP 61277680 A2 8 Dec 1986 Showa, 5 pp. (Japan) CODEN: JKXXAF. CLASS: ICM: C07D401-04. ICI: C07D401-04, C07D213-00, C07D233-00; C07D401-04, C07D215-00, C07D233-00. APPLICATION: JP 86-119419 26 May 1986. PRIORITY: US 85-737964 28 May 1985. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 5 The title compds. [I; R1 = C1-4 alkyl; R2 = C1-4 alkyl, C3-6 cycloalkyl; R3 = H, C1-4 alkyl; R4 = H, halo, C1-4 alkyl(oxy), C1-4 alkylthio, trihalomethyl, HF2CO, (un)substituted Ph, dialkylamino; R5 = H, C1-4 alkyl, trihalomethyl, (un)substituted Ph or R4R5 = (un)substituted 1,3-butedienylidene], useful as plant active compds. (no data), were prepd. Thus, MeCOCHMe2 in MeOH was added dropwise at >28° to a soln. of KCN in H2O contg. NH4Cl and NaOH and the resulting mixt. was heated at 57° for 17 h to give MeC(CN)(NH2)CHMe2. Treatment of this with concd. H2SO4 at room temp. for 3 days and reaction of the resulting H2NCOCMe(NH2)CHMe2 with 2,3-quinolinedicarboxylic acid anhydride in toluene contg. Et3N at b. temp. for 24 gave a quinoline deriv. II (R1 = Me, R2 = CHMe2). .