Reference

Comparative study of intestinal antispasmodic properties of metoclopramide and metopimazine

Comparative study of intestinal antispasmodic properties of metoclopramide and metopimazine. Barale, F.; Berthet, F.; Magnin, P. (Lab. Anesth. Exp., Fac. Med. Pharm., Besancon, Fr.). Anesth., Analg., Reanim., 34(1), 47-54 (French) 1977. CODEN: AAREAV. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Both metoclopramide (I) [364-62-5] and metopimazine (II) [14008-44-7] had intestinal-spasmolytic activity in mice, as shown by their slowing the intestinal transit of a test meal. At equal doses, II was more effective than I; the latter, when given i.p., was 0.1 as active as atropine. Tests on the isolated guinea pig ileum also showed both I and II to be spasmolytic. I inhibited the contractions induced by acetylcholine, histamine, and BaCl2, indicating both a neurotropic and a musculotropic action. II, on the other hand, was neurotropic only. The mean effective concn. of both drugs was 50 .mu.g/mL for blocking the effects of acetylcholine chloride and histamine-HCl at 10 .mu.g/mL.

The pharmacological action of 3-methylsulfonyl-10-(3-(4'-carbamoylpiperidino)propyl)phenothiazine (9965RP)

The pharmacological action of 3-methylsulfonyl-10-(3-(4'-carbamoylpiperidino)propyl)phenothiazine (9965RP). 1. Acute toxicity and respiratory and cardiovascular actions. Matsumura, Shoichi; Kimoto, Sadatoshi; Morishige, Eiichi; Uno, Osamu; Haruna, Masao; Minesita, Tetsuo (Shionogi Res. Lab., Shionogi and Co., Ltd., Osaka, Japan). Oyo Yakuri, 11(4), 561-77 (Japanese) 1976. CODEN: OYYAA2. ISSN: 0369-8033. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) 9965 RP (I) [14008-44-7], administered orally to cats, dogs, guinea pigs, mice, rabbits, and rats, depressed the central nervous system. I increased the respiratory rate in cats and rabbits after i.v. injection but inhibited respiration and decreased blood pressure when administered intracisternally. The pharmacol. effects of I were, in general, less than those of chlorpromazine.