Detail of "14099-81-1"

CAS Number:
14099-81-1
Name:
Isoquinoline,1,2,3,4-tetrahydro-, hydrochloride (1:1)
Molecular Structure:
Formula:
C₉H₁₂ClN
Molecular Weight:
169.65
Synonyms:
Isoquinoline,1,2,3,4-tetrahydro-, hydrochloride (6CI,8CI,9CI);1,2,3,4-Tetrahydroisoquinoline hydrochloride;
Density:
1.006 g/cm³
Melting Point:
198-202 °C
Boiling Point:
232.5 °C at 760 mmHg
Flash Point:
98.9 °C
Appearance:
white to off-white crystalline powder
Hazard Symbols:
Xn, Xi
Risk Codes:
36/37/38-20/21/22
Safety:
36/37/39-26-37/39 Details

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Physicochemical properties and membrane action of spasmolytically active isoquinoline and 1,2,3,4-tetrahydroisoquinoline derivatives: Physicochemical properties and membrane action of spasmolytically active isoquinoline and 1,2,3,4-tetrahydroisoquinoline derivatives. Simon, L.; Porszasz, J.; Gibiszerkatalin, P.; Talpas, S. G. (Pharm.-Chem. Inst., Med. Univ. Szeged, Szeged, Hung.). Pharmazie, 32(4), 235-9 (German) 1977. CODEN: PHARAT. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Papaverine [58-74-2], ethaverine [486-47-5], drotaverine [14009-24-6], 1-phenyl-6,7-dimethoxyisoquinoline-HCl [63768-18-3], 6,7-dimethoxyisoquinoline-HCl [63768-19-4], and isoquinoline-HCl [21364-46-5] at pH 7.6 increased the transmembrane potential and compensation current in isolated frog skin. A pH 5.9 they had an opposite effect. The 1,2,3,4-tetrahydroisoquinoline derivs., 1,2,3,4-tetrahydroisoquinoline-HCl [14099-81-1], 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-HCl [2328-12-3], 1-phenyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-HCl [63768-20-7], 1-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline [3423-37-8], 1-p-chlorophenyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline [55507-15-8], 1-p-carbethoxyphenyl-6,7-dimethoxy,-1,2,3,4-tetrahydroisoquinoline-H Cl [52947-23-6], 1-p-nitrophenyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-HCl [4728-52-3], decreased transmembrane potential at pH 7.6. The hydrophilic and basic properties of the isoquinoline derivs. were presented.