14099-81-1

Basic information

• Product Name: 1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
• Synonyms: 1,2,3,4-tetrahydro-isoquinolinhydrochloride;1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE;TIMTEC-BB SBB003860;1,2,3,4-Tetrahydroisoquinoline HCl;Isoquinoline, 1,2,3,4-tetrahydro-, hydrochloride;1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 98+%
• CAS NO: 14099-81-1
• Molecular Formula: C₉H₁₂N*Cl
• Molecular Weight: 169.65
• EINECS: 202-050-0
• Mol File: 14099-81-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 198-202 °C
• Boiling Point: 232.5 °C at 760 mmHg
• Flash Point: 98.9 °C
• Appearance: white to off-white crystalline powder
• Density: 1.006 g/cm³
• Vapor Pressure: 0.0588mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: almost transparency
• CAS DataBase Reference: 1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE(14099-81-1)
• EPA Substance Registry System: 1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE(14099-81-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26-37/39
• RTECS: NX5075000
• Hazardous Substances Data: 14099-81-1(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white crystalline powder

InChI:InChI=1/C9H11N.ClH/c1-2-4-9-7-10-6-5-8(9)3-1;/h1-4,10H,5-7H2;1H

Upstream product

• 1071-71-2 ethyl 6-chloro-6-oxohexanoate 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 1066-45-1 trimethyltin(IV)chloride 
• 5666-67-1 1,2,3,4-Tetrahydroisoquinolinium 1,3,4-Trihydroisoquinoline-2-carbodithioate 
• 7647-01-0 hydrogenchloride 
• 14429-05-1 3.4-dihydro isoquinoline borane 

Downstream Products

• 676994-40-4 2-[4-(3,5-dichloro-phenoxy)-5-methyl-2H-pyrazol-3-yl]-1-(3,4-dihydro-1H-isoquinolin-2-yl)-ethanone 
• 676994-52-8 5-{5-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-ethyl]-3-methyl-1H-pyrazol-4-yloxy}-isophthalonitrile 
• 14028-67-2 N-acetyl-1,2,3,4-tetrahydroisoquinoline 
• 1236265-22-7 4-((4-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-Nethyl-N-methylbenzamide 
• 1236265-93-2 4-((4-chloro-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-methylbenzamide 
• 1236265-10-3 4-((4-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-Nethyl-N-m-tolylbenzamide 
• 1236264-74-6 4-((4-(benzylamino)-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide 
• 1236265-89-6 4-((4-chloro-6-(3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide 
• 1236265-19-2 4-((2-amino-6-(3,4-dihydroisoquinolin-2(1H)-yl)pyrimidin-4-ylamino)methyl)-N-ethyl-.N-m-tolylbenzamide 
• 1236265-15-8 4-((6-(3,4-dihydroisoquinolin-2(1H)-yl)-2-methylpyrimidin-4-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide 
• 1236265-12-5 4-((6-(3,4-dihydroisoquinolin-2(1H)-yl)pyrimidin-4-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide 
• 4836-98-0 1,2,3,4-tetrahydro-2-amino-isoquinoline 

Relevant articles and documents

Dynamic Kinetic Resolution of Alcohols by Enantioselective Silylation Enabled by Two Orthogonal Transition-Metal Catalysts

A nonenzymatic dynamic kinetic resolution of acyclic and cyclic benzylic alcohols is reported. The approach merges rapid transition-metal-catalyzed alcohol racemization and enantioselective Cu-H-catalyzed dehydrogenative Si-O coupling of alcohols and hydrosilanes. The catalytic processes are orthogonal, and the racemization catalyst does not promote any background reactions such as the racemization of the silyl ether and its unselective formation. Often-used ruthenium half-sandwich complexes are not suitable but a bifunctional ruthenium pincer complex perfectly fulfills this purpose. By this, enantioselective silylation of racemic alcohol mixtures is achieved in high yields and with good levels of enantioselection.

Direct Preparation of Amides from Amine Hydrochloride Salts and Orthoesters: A Synthetic and Mechanistic Perspective

The conversion of a wide range of primary and secondary aliphatic and a few arylamine hydrochloride salts to their corresponding acetamides with trimethyl orthoacetate is described. Mechanistic studies using NMR and gas chromatography-mass spectrometry techniques indicate these reactions proceed via an O-methylimidate intermediate that undergoes in situ demethylation by chloride, affording the corresponding acetamides. Synthetically, this reaction represents a practical, high-yielding protocol with a simple workup for the rapid conversion of amine hydrochloride salts to acetamides.

New supramolecular triorganotin(IV) dithiocarboxylates as potential antibacterial agents

Four triorganotin derivatives of general formula C10H 10NS2SnR3,, where R = CH3 (1), C4H9 (2), C6H11 (3), and C6H5 (4), have been synthesized by the metathesis reaction of 1,2,3,4-tetrahydroisoquinolnium salt of ligand with triorganotin(IV) chloride in the 1:1 ratio. These complexes were characterized by elemental analysis, Raman, IR, multinuclear NMR (1H, 13C, and 119Sn), and mass spectrometry. The crystal structure confirmed a supramolecular zig-zag chain structure mediated by S-H (2.968 A) for complex 4 with the central Sn atom exists in a distorted trigonal bipyramidal geometry. A subsequent antibacterial study indicates that the compounds are biologically active.