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Detail of "141-90-2"

  • CAS Number:
  • 141-90-2
  • Name:
  • 4(1H)-Pyrimidinone,2,3-dihydro-2-thioxo-

  • Superlist Name:
  • 2-Thiouracil
  • Molecular Structure:
  • Formula:
  • C4H4N2OS
  • Molecular Weight:
  • 128.15
  • Deleted CAS:
  • 107646-88-8|107646-89-9|156-82-1|4401-53-0|4401-54-1
  • Synonyms:
  • Uracil,2-thio- (8CI);2-Mercapto-4-hydroxypyrimidine;2-Mercapto-4-pyrimidinol;2-Mercapto-4-pyrimidinone;4-Hydroxy-2-mercaptopyrimidine;4-Hydroxy-2-pyrimidinethiol;6-Hydroxy-2-mercaptopyrimidine;Antagothyroil;Deracil;NSC 19473;NSC 290412;NSC 290413;NSC 290414;Nobilen;Thiouracil;
  • EINECS:
  • 205-508-8
  • Density:
  • 1.46 g/cm3
  • Melting Point:
  • >300 °C(lit.)
  • Boiling Point:
  • 337.2 °C at 760 mmHg
  • Flash Point:
  • 157.7 °C
  • Solubility:
  • 0.5 g/L in water
  • Appearance:
  • white to cream fine crystalline powder
  • Hazard Symbols:
  • HarmfulXn,ToxicT
  • Risk Codes:
  • 40-45-20/21/22
  • Safety:
  • 36/37-53-45 Details
  • particular:
  • particular

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CAS No.141-90-2 2-ThiouracilCompetitive Product

Supplier:Dishman Pharmaceuticals & Chemicals Co., Ltd. [ China (Mainland)]

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CAS No.141-90-2 2-Thiouracil

  Package:in 25kgs car...Storage:normal condi...  Transportation:non dangerou...  Application:intermediate...

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CAS No.141-90-2 2-Thiouracil

Assay:98℅  Appearance:Inqury  Package:100g,500g,12...

Supplier:Shanghai DEMO Medical Tech Co.,Ltd [ China (Mainland)]

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CAS No.141-90-2 2-Thiouracil

Assay:98%

Supplier:Hangzhou Dayangchem Co., Ltd. [ China (Mainland)]

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CAS No.141-90-2 2-Thiouracil

2-Thiouracil

Supplier:CHEMIMPEX INT'L INC [ United States]

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CAS No.141-90-2 2-Thiouracil

2-Thiouracil

Supplier:Pharmacn Laboratories [ China (Mainland)]

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CAS No.141-90-2 2-Thiouracil

Supplier:HuiDe Tech Industrial Co., Ltd. [ China (Mainland)]

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CAS No.141-90-2 2-Thiouracil

Supplier:Shijiazhuang JuSha Imp. & Exp. Co., Ltd [ China (Mainland)]

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CAS No.141-90-2 2-Thiouracil

Supplier:Hangzhou Share Chemical Co., Ltd [ China (Mainland)]

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CAS No.141-90-2 2-Thiouracil

Assay:99%  Appearance:white powder  Package:25kg/drum

Supplier:Ningbo EST Chemical Co., Ltd [ China (Mainland)]

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CAS No.141-90-2 2-Thiouracil

2-Thiouracil

Supplier:Hisyntech Corporation Limited [ China (Mainland)]

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CAS No.141-90-2 2-Thiouracil

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Supplier:AB Chem Technologies, LLC [ United States]

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CAS No.141-90-2 2-Thiouracil

more information,please contact us

Supplier:Ibis Chemie International [ India]

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CAS No.141-90-2 2-Thiouracil

2-THIOURACIL

Supplier:IS Chemicals Co., Ltd. [ Korea]

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CAS No.141-90-2 2-Thiouracil

Supplier:IS Chemicals Co., Ltd. [ Korea]

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CAS No.141-90-2 2-Thiouracil

Supplier:Hubei Hengluyuang Technology Co.,Ltd [ China (Mainland)]

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CAS No.141-90-2 2-Thiouracil

Supplier:Naugra Export [ India]

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CAS No.141-90-2 2-Thiouracil

Supplier:Dishman Europe Ltd. [ United Kingdom]

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CAS No.141-90-2 2-Thiouracil

Supplier:HBCChem, Inc. [ United States]

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CAS No.141-90-2 2-Thiouracil

Supplier:Dhruvtara Chemicals Pvt Ltd [ India]

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Reference

Depressed hypothalamic CRF immunoreactivity in 15 day old thiouracil-treated rats
Depressed hypothalamic CRF immunoreactivity in 15 day old thiouracil-treated rats. Meserve, L. A. (Dep. Biol. Sci., Bowling Green State Univ., Bowling Green, OH 43403, USA). Horm. Metab. Res., 16(12), 674-5 (English) 1984. CODEN: HMMRA2. ISSN: 0018-5043. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Thiouracil [141-90-2] prenatal administration decreased the body wt. and increased the thyroid gland wt. in 15-day-old rats. Adult rat hypothalamus contained 1 ng radioimmunoassayable CRF [9015-71-8]/rat. Thiouracil feeding of 15-day-old rats decreased the hypothalamic immunoreactive CRF from 355 to 140 pg/hypothalamus. However, all 15-day-old rats had lower hypothalamic radioimmunoassayable CRF than did adults. Thus, thiouracil prenatal treatment causes a CRF deficiency in 15-day-old rats.
Effects of propylthiouracil on D-galactosamine hepatotoxicity in the rat
Effects of propylthiouracil on D-galactosamine hepatotoxicity in the rat. Evidence for a nonthyroidal effect. Cooper, David S.; Carter, Edward A.; Kieffer, J. David; Wands, Jack R. (Dep. Med., Massachusetts Gen. Hosp., Boston, MA 02114, USA). Biochem. Pharmacol., 33(21), 3391-7 (English) 1984. CODEN: BCPCA6. ISSN: 0006-2952. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 4 The cytoprotective effects of propylthiouracil (PTU) [51-52-5] were studied in rats treated with the hepatotoxin D-galactosamine (D-GNH2) [7535-00-4]. Five days of PTU pretreatment prior to D-GNH2 caused hypothyroidism and a significant redn. in liver injury as assessed by serum transaminase levels. When PTU was administered as a single dose with D-GNH2, significant decreases in transaminase also occurred at times when thyroid function was unchanged. Furthermore, aminopyrine oxidn. showed a significant impairment after D-GNH2 and was normalized by one dose of PTU. Further studies were carried out in thyroidectomized rats. PTU caused significant redns. in transaminase levels when given for 5 days pretreatment or as a single dose. Animals receiving pretreatment with PTU plus thyroxine (T4) [51-48-9] also had significant decreases in serum transaminase. The antithyroid drug methimazole [60-56-0] also had a hepatoprotective effect, while 2 other potent antithyroid compds. (2-thiouracil [141-90-2] and 2-thiobarbituric acid [504-17-6]) did not. These data suggest that PTU can protect against liver injury induced by D-GNH2, that the effect is independent of thyroid function, and that this effect is not common to all thiol-contg. antithyroid drugs.
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