2-THIOURACIL
(141-90-2)
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Required Fields
Chemistry
Molecular Formula: C
4H
4N
2OS
Formula Weight: 128.15
Melting point: >300
°C(lit.)
Flash Point of 2-THIOURACIL (141-90-2): 157.7
°C
Boiling Point: 337.2
°C at 760 mmHg
Density of 2-THIOURACIL (141-90-2): 1.46 g/cm
3 Vapour Pressure: 5.45E-05 mmHg at 25
°C
storage temp. : 2-8
°C
Index of Refraction: 1.677
Water Solubility : 0.5 g/L
PHYSICAL STATE of 2-THIOURACIL (141-90-2): white to pale yellow crystalline powder
Uses
2-THIOURACIL (141-90-2) is the basic structure of several drugs used to treat hyperthyroidism. In industry 2-THIOURACIL (141-90-2) is used in galvanization as a grain refining agent.
Toxicity Data With Reference
| 1. |
|
pic-esc 100 mmol/L |
|
MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. 31 (1979),11. |
| 2. |
|
orl-mus LD50:3900 mg/kg |
|
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. 44 (1955),56. |
| 3. |
|
orl-rbt LDLo:3700 mg/kg |
|
MEIEDD Merck Index. 10 (1983),1342. |
Consensus Reports
IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1974,p. 85.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Safety Profile
Safety: CAUTION: May irritate eyes, skin, and respiratory tract
Hazard Codes : Xn (Harmful)
Risk Statements : 40 (Limited evidence of a carcinogenic effect)
Safety Statements : 36/37 (Wear suitable protective clothing and gloves)
WGK Germany : 3
RTECS : YR1575000
HS Code : 29335995
Moderately toxic by ingestion. Human teratogenic effects by unspecified routes: developmental abnormalities of the central nervous system, craniofacial area, and endocrine system. Human reproductive effects by unspecified route: effects on newborn, including viability index changes. Experimental teratogenic effects. Other experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO
x and SO
x. Used in the treatment of hyperthyroidism, angina pectoris, and congestive heart failure. See also
MERCAPTANS and
KETONES.
Standards and Recommendations
PURITY: 97.0% min
Specification
Storage: Store in a cool, dry, well-ventilated area away from incompatible substances. Hormones and antibiotics room. Store in a tightly closed container. Keep container closed when not in use.
