CAS No.14293-44-8,Xipamide Suppliers

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Basic Information

Molecular Structure:
CAS No.:	14293-44-8
Name:	Xipamide
Article Data:	2

Formula:	C₁₅H₁₅ClN₂O₄S
Molecular Weight:	354.814
Synonyms:	2',6'-Salicyloxylidide,4-chloro-5-sulfamoyl- (8CI);Aquaphor;Aquaphor (diuretic);BE 1293;BEI 1293;Chronexan;Diurex (Lacer);Diurexan;Lumitens;MJF 10938;
EINECS:	238-216-4
Density:	1.477 g/cm³
Melting Point:	255-256 °C
Solubility:	58mg/L(25 oC)
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26
PSA:	117.87000
LogP:	4.41620

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Chemistry

Product Name: Xipamide (CAS NO.14293-44-8)

MF: C₁₅H₁₅ClN₂O₄S
MW: 354.81
Index of Refraction: 1.652
Melting Point: 255-256 °C
EINECS: 238-216-4
Index of Refraction: 1.652
Molar Refractivity: 87.89 cm³
Molar Volume: 40.1 cm³
Surface Tension: 67.1 dyne/cm
Density: 1.477 g/cm³
XLogP3-AA: 2.9
H-Bond Donor: 3
H-Bond Acceptor: 5
Structure Descriptors of Xipamide (CAS NO.14293-44-8):
IUPAC Name: 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide
Canonical SMILES: CC1=C(C(=CC=C1)C)NC(=O)C2=CC(=C(C=C2O)Cl)S(=O)(=O)N
InChI: InChI=1S/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22)
InChIKey: MTZBBNMLMNBNJL-UHFFFAOYSA-N
Product Categories: APIs; Xipamide

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	> 50mg/kg (50mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 245, 1975.
dog	LD50	oral	> 1500mg/kg (1500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 245, 1975.
mouse	LD50	intraperitoneal	520mg/kg (520mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 245, 1975.
mouse	LD50	oral	877mg/kg (877mg/kg)		United States Patent Document. Vol. #4490368,
mouse	LD50	subcutaneous	1480mg/kg (1480mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 245, 1975.
rat	LD50	intraperitoneal	320mg/kg (320mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 245, 1975.
rat	LD50	oral	1640mg/kg (1640mg/kg)	BEHAVIORAL: ATAXIA BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 245, 1975.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of Cl⁻, SO_x, and NO_x.

Specification

Xipamide , its CAS NO. is 14293-44-8, the synonyms are 4-Chloro-2',6'-dimethyl-5-sulfamoylsalicylanilide ; 4-Chloro-5-sulfamylsalicyloyl-2',6'-dimethylanilide ; 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide ; 5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxybenzamide ; Benzamide, 5-(aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy- ; 2',6'-Salicyloxylidide, 4-chloro-5-sulfamoyl- .