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CAS No.: | 1448-87-9 |
---|---|
Name: | 2-Chloroquinoxaline |
Article Data: | 56 |
Molecular Structure: | |
Formula: | C8H5ClN2 |
Molecular Weight: | 164.594 |
Synonyms: | 2-Chloroquinoxaline;NSC 43553; |
EINECS: | 215-905-8 |
Density: | 1.35 g/cm3 |
Melting Point: | 47-50 °C(lit.) |
Boiling Point: | 252.919 °C at 760 mmHg |
Flash Point: | 131.229 °C |
Hazard Symbols: | T,Xn |
Risk Codes: | 25-36/37/38-22 |
Safety: | 26-36/37/39-45 |
Transport Information: | UN 2811 6.1/PG 3 |
PSA: | 25.78000 |
LogP: | 2.28320 |
Conditions | Yield |
---|---|
With pyridine; trichlorophosphate at 160℃; for 2h; Autoclave; neat (no solvent); | 94% |
With dmap; thionyl chloride; bis(trichloromethyl) carbonate for 6.5h; Reflux; Green chemistry; | 94% |
With P,P-dichlorophenylphosphine oxide at 110℃; for 12h; Inert atmosphere; | 81% |
Conditions | Yield |
---|---|
With trichlorophosphate In toluene for 1h; Reflux; | 93% |
With N-chloro-succinimide; triphenylphosphine In 1,4-dioxane for 4h; Heating; | 88% |
With trichloroisocyanuric acid; triphenylphosphine In toluene for 4h; Heating; | 77% |
Conditions | Yield |
---|---|
at 390 - 400℃; | A 12% B 88% |
2,6-dichloroquinoxaline
2-chloroquinoxaline
Conditions | Yield |
---|---|
With 18-crown-6 ether; 4 A molecular sieve; cesium fluoride In tetrahydrofuran for 20h; Product distribution; Ambient temperature; other 6-substituted 2-chloroquinoxalines; var. temp., reaction time and stoichiometry of reagents; | 87% |
Conditions | Yield |
---|---|
With sodium dimethyl phosphonate In tetrahydrofuran at 20℃; for 4h; | 85% |
C22H15N3O2
A
2-chloroquinoxaline
B
benzophenone
C
hexachloroethane
D
benzophenone azine
Conditions | Yield |
---|---|
With tetrachloromethane Ambient temperature; Irradiation; Yields of byproduct given; | A 74% B n/a C n/a D n/a |
Conditions | Yield |
---|---|
With N,N-dimethyl-formamide; trichlorophosphate In dichloromethane at 0 - 25℃; Inert atmosphere; regioselective reaction; | 63% |
With trichlorophosphate |
2-chloroquinoxaline
Conditions | Yield |
---|---|
With lithium chloride In 1,4-dioxane at 80℃; for 24h; Inert atmosphere; Sealed tube; regioselective reaction; | 60% |
A
2-chloroquinoxaline
Conditions | Yield |
---|---|
at 450℃; under 0.01 Torr; | A 54% B n/a |
at 450℃; under 0.01 Torr; | A n/a B 54% |
quinoxalin-2(1)-one
A
2-chloroquinoxaline
B
2-chloroquinoxaline-6-sulfonyl chloride
Conditions | Yield |
---|---|
With chlorosulfonic acid; thionyl chloride at 110℃; for 11h; | A 8.5 g B 44% |
Molecular Structure:
Molecular Formula: C8H5ClN2
Molecular Weight: 164.5917
IUPAC Name: 2-Chloroquinoxaline
Synonyms of 2-Chloroquinoxaline (CAS NO.1448-87-9): EINECS 215-905-8 ; 2-Chloroquinoxaline ,99% ; Chloroquinoxaline
CAS NO: 1448-87-9
Product Categories: Building Blocks ; Halogenated Heterocycles ; Heterocyclic Building Blocks ; Quinoxalines ; QuinoxalinesHeterocyclic Building Blocks
Melting point: 47-50 °C
Index of Refraction: 1.662
Molar Refractivity: 45.17 cm3
Molar Volume: 121.9 cm3
Surface Tension: 57.1 dyne/cm
Density: 1.349 g/cm3
Flash Point: 131.2 °C
Enthalpy of Vaporization: 47.05 kJ/mol
Boiling Point: 252.9 °C at 760 mmHg
Vapour Pressure: 0.03 mmHg at 25°C
2-Chloroquinoxaline (CAS NO.1448-87-9) is used for pharmaceutical and agricultural chemical intermediates.
Hazard Codes of 2-Chloroquinoxaline (CAS NO.1448-87-9): T,Xn
Risk Statements: 25-36/37/38-22
R25: Toxic if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R22: Harmful if swallowed.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
HazardClass: IRRITANT