Welcome to LookChem.com Sign In|Join Free
  • or
Home > Pharmaceutical > 147254 > 

147254-64-6

Products Categories

Basic Information
CAS No.: 147254-64-6
Name: (3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone
Article Data: 6
Molecular Structure:
Molecular Structure of 147254-64-6 ((3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone)
Formula: C17H11 Br F N3 O4
Molecular Weight: 420.194
Synonyms: Spiro[pyrrolidine-3,4'(1'H)-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone,2'-[(4-bromo-2-fluorophenyl)methyl]-, (-)-;Spiro[pyrrolidine-3,4'(1'H)-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone,2'-[(4-bromo-2-fluorophenyl)methyl]-, (3'R)- (9CI);(3R)-2'-(4-Bromo-2-fluorobenzyl)-1',2',3',4'-tetrahydrospiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5-tetraone;AS 3201; Ranirestat
Density: 1.83g/cm3
Melting Point: 192-193℃
Boiling Point: 702.7°Cat760mmHg
Flash Point: 378.8°C
PSA: 91.97000
LogP: 1.52790
Related products
Synthetic route
1211939-75-1

(S)-methyl 4-(2-amino-2-oxoethyl)-2-(4-bromo-2-fluorobenzyl)-1,3-dioxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-carboxylate

147254-64-6

ranirestat

Conditions
ConditionsYield
With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; Inert atmosphere;95%
112734-22-2

4-bromo-2-fluorobenzylamine

159213-26-0

R-(-)-3-ethoxycarbonyl-3-(2-(trichloroacetyl)pyrrol-1-yl)pyrrolidin-2,5-dione

147254-64-6

ranirestat

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 5h;71%
With triethylamine In N,N-dimethyl-formamide at 20℃;65%
With triethylamine In N,N-dimethyl-formamide at 20℃; for 8h;65%
1000784-39-3

(2R)-2-ethoxycarbonyl-2-(pyrrol-1-yl)succinimide diisopropylamine salt

112734-22-2

4-bromo-2-fluorobenzylamine

147254-64-6

ranirestat

Conditions
ConditionsYield
Stage #1: (2R)-2-ethoxycarbonyl-2-(pyrrol-1-yl)succinimide diisopropylamine salt With sulfuric acid; water In ethyl acetate
Stage #2: With trifluoroacetyl chloride In ethyl acetate for 6h; Heating / reflux;
Stage #3: 4-bromo-2-fluorobenzylamine With water; sodium hydrogencarbonate; diisopropylamine more than 3 stages;		58%

(4-bromo-2-fluorophenyl)methanamine hydrochloride

159213-26-0

R-(-)-3-ethoxycarbonyl-3-(2-(trichloroacetyl)pyrrol-1-yl)pyrrolidin-2,5-dione

147254-64-6

ranirestat

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide for 16h; Ambient temperature;45%
159213-18-0

(R)-ethyl-3-amino-2,5-dioxopyrrolidine-3-carboxylate

147254-64-6

ranirestat

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 72.4 percent / AcOH / 1.5 h / 70 °C
2: 91.9 percent / CHCl3 / 16 h / Heating
3: 45 percent / Et3N / dimethylformamide / 16 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1.1: water / Heating
1.2: 22; 13 / 12 h / 40 °C
2.1: 10 h / 80 °C
3.1: N,N-dimethyl-formamide / 5 h / 20 °C
View Scheme
159213-19-1

ethyl 2,5-dioxo-3-(1H-pyrrol-1-yl)pyrrolidine-3-carboxylate

147254-64-6

ranirestat

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91.9 percent / CHCl3 / 16 h / Heating
2: 45 percent / Et3N / dimethylformamide / 16 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: ethyl acetate / Reflux
2: triethylamine / N,N-dimethyl-formamide / 8 h / 20 °C
View Scheme
147194-10-3

ethyl 3-benzyloxycarbonylamino-2,5-dioxopyrrolidine-3-carboxylate

147254-64-6

ranirestat

Conditions
ConditionsYield
Multi-step reaction with 5 steps
2: 95.9 percent / H2 / 5percent Pd/C / ethanol / 40 - 50 °C / 760 Torr
3: 72.4 percent / AcOH / 1.5 h / 70 °C
4: 91.9 percent / CHCl3 / 16 h / Heating
5: 45 percent / Et3N / dimethylformamide / 16 h / Ambient temperature
View Scheme
159213-17-9

(R)-2-benzyloxycarbonylamino-2-ethoxycarbonylsuccinimide

147254-64-6

ranirestat

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 95.9 percent / H2 / 5percent Pd/C / ethanol / 40 - 50 °C / 760 Torr
2: 72.4 percent / AcOH / 1.5 h / 70 °C
3: 91.9 percent / CHCl3 / 16 h / Heating
4: 45 percent / Et3N / dimethylformamide / 16 h / Ambient temperature
View Scheme
952656-32-5

ethyl (R)-3-hydrazinyl-2,5-dioxopyrrolidine-3-carboxylate hydrochloride

147254-64-6

ranirestat

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogen / nickel / ethanol / 42 h / 20 °C
2.1: water / Heating
2.2: 22; 13 / 12 h / 40 °C
3.1: 10 h / 80 °C
4.1: N,N-dimethyl-formamide / 5 h / 20 °C
View Scheme

R-(-)-3-ethoxycarbonyl-3-(N,N'-di(tert-butoxycarbonyl)hydrazino)pyrrolidin-2,5-dione hydrochloride

147254-64-6

ranirestat

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogenchloride / toluene / 2.5 h / 0 °C
2.1: hydrogen / nickel / ethanol / 42 h / 20 °C
3.1: water / Heating
3.2: 22; 13 / 12 h / 40 °C
4.1: 10 h / 80 °C
5.1: N,N-dimethyl-formamide / 5 h / 20 °C
View Scheme
Hot Products
  • Display:default sort

    New supplier

  • Ranirestat

  • Casno:

    147254-64-6

    Ranirestat

    Min.Order: 10 Gram

    FOB Price:  USD $ 100.0-100.0

    Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

    Hangyu Biotech is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and O

  •  Zibo Hangyu Biotechnology Development Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-15965530500

    Address:Room1701, Tianxing Building,Licheng district, jinan, Shandong, China

       Inquiry Now

  • Ranirestat

  • Casno:

    147254-64-6

    Ranirestat

    Min.Order: 1 Milligram

    FOB Price:  USD $ 0.0-0.0

    GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

  •  Xiamen Jenny Chemical Technology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86

    Address:xiameng

       Inquiry Now

  • Ranirestat CAS No.147254-64-6

  • Casno:

    147254-64-6

    Ranirestat CAS No.147254-64-6

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

    Guangdong Juda Chemical Industrial Co.,Limited is a company specializing in APIs,pharmaceutical intermediates, electronic chemicals, plant extracts,fine chemicals and cosmetics raw

  •  Guangdong Juda Chemical Industrial Co.,Limited

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86 13510152023(whatsapp)

    Address:Guangzhou chemical city Tianhe District Guangzhou Guangdong China

       Inquiry Now

  • Raniestat

  • Casno:

    147254-64-6

    Raniestat

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:clear liquid Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as primary a

    BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-info

  •  BOC Sciences

    United States  |  Contact Details

    Business Type:Trading Company

    Tel:1-631-485-4226

    Address:Ramsey Road

       Inquiry Now

  • Ranirestat

  • Casno:

    147254-64-6

    Ranirestat

    Min.Order: 10 Milligram

    FOB Price:  USD $ 0.0-0.0

    1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

    Founded in 2011, Amadis Chemical Company Limited is an innovative manufacturer of chemical products and technical service providers. Our business includes sales, manufacture, and s

  • Amadis Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-571-89925085

    Address:Watts Cosine.No.166.Xiangmao Road.

       Inquiry Now

  • Ranirestat

  • Casno:

    147254-64-6

    Ranirestat

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0

    good quality and best price Application:R&D for pharmaceutical Port:Shanghai

    ShoChem Co. Ltd (Shochem) is mainly engaged in development of highly value-added pharmaceutical intermediates, fine chemicals, API synthesis, and the above process optimization. We

  • Shochem(Shanghai) Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:021-50800795

    Address:No.1043, Halei Rd, Zhangjiang Hi-Tech Park, Shanghai, Postcode 201203, China

       Inquiry Now

  • Ranirestat,147254-64-6

  • Casno:

    147254-64-6

    Ranirestat,147254-64-6

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    instock with good quality and wholesale price Storage:Keep in a cool & dry place Package:Packing material and QTY as your request Application:Pharma;Industry;other application Transportation:Express or as your request Port:Any port of China

    Wuhan MoonZY Biological Technology Co.,Ltd (MoonzyBio)is located in Wuhan city,hubei province,China,we have a group of senior technical backbones, specialized in R & D and sales in

  • Wuhan MoonZY Biological Technology Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:13545198479

    Address:203,Building 3, International Enterprise Center, No. 1 Guanshan 2nd Road, East Lake New Technology Development Zone,

       Inquiry Now

  • 147254-64-6

  • Casno:

    147254-64-6

    147254-64-6

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Supply top quality products with a reasonable price Application:api

    Hebei Ruishun Trade Co.,Ltd registered capital one million, we have a production of pharmaceutical raw materials, pharmaceutical raw materials factory reagent r&d center, we do

  • Hebei Ruishun Trade Co.,Ltd

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-311-68037669

    Address:WanDa commerce building ,yuhua district

       Inquiry Now

  • RANIRESTAT

  • Casno:

    147254-64-6

    RANIRESTAT

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers.Appearance:yellow to white solid Storage:keep sealed and keep from direct light Package:According client's requirements Application:Phar

    Jinan YSPharma Biotechnology Co., Ltd is a large group specializing in contract manufacturing to the pharmaceutical, agrochemical and Fine chemicals with top quality products and s

  • coolpharm Ltd

    China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:86-531-8233381 86-18678657237

    Address:Room 302,Building 1,Union Fortune Square, No. 2117,Tianchen Road,High-tech Zone,Jinan,Shandong,China

       Inquiry Now

  • Ranirestat

  • Casno:

    147254-64-6

    Ranirestat

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

      Shanghai Haoyuan Chemexpress is an innovative company, which is located in Zhangjiang High-tech Park in Shanghai, China. we are specialized in custom synthesis of or

  • Shanghai Haoyuan Chemexpress Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-21-51870955;58998985;58999585

    Address:Room 601, No. 2 BLD, NO. 720, Cailun Road, Zhangjiang, Shanghai, China

       Inquiry Now

  • Total:18 Page 1 of 1 1
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 147254-64-6