Detail of "149-64-4"

CAS Number:
149-64-4
Name:
3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,9-butyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-, bromide (1:1), (1a,2b,4b,5a,7b)-
Superlist Name:
Scopolamine butylbromide
Molecular Structure:
Formula:
C₂₁H₃₀NO₄.Br
Molecular Weight:
440.37
Synonyms:
1aH,5aH-Tropanium, 8-butyl-6b,7b-epoxy-3a-hydroxy-,bromide, (-)-tropate (8CI);3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,9-butyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-, bromide, (1a,2b,4b,5a,7b)- (9CI);N-Butylscopolammonium bromide (6CI,7CI);(-)-Scopolaminebutylbromide;N-Butylhyoscinium bromide;N-Butylscopolaminium bromide;
EINECS:
205-744-1
Melting Point:
142-144 °C
Solubility:
Water: 50 mg/mL
Appearance:
White crystalline solid
Hazard Symbols:
Xn
Risk Codes:
22

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Reference

Effects of spasmolytics on potassium-induced contraction of rat intestine in vivo: Effects of spasmolytics on potassium-induced contraction of rat intestine in vivo. Subissi, Alessandro; Brunori, Paola; Bachi, Moreno (Dep. Pharmacol., Lab. Guidotti S.p.A., Pisa 56010, Italy). Eur. J. Pharmacol., 96(3-4), 295-301 (English) 1983. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Eight spasmolytic drugs commonly used in the treatment of the irritable bowel syndrome were compared to verapamil [52-53-9] with respect to their effects (all drugs injected i.v.) on the contraction of duodenum, ileum, and colon induced by high-K+ topical application in the anesthetized rat. Verapamil > rociverine citrate [89026-32-4] > papaverine [58-74-2] > mebeverine [3625-06-7] > dicyclomine [77-19-0] antagonized dose-dependently the contraction of duodenum and colon, the activity on duodenum being from 2- (rociverine) to 10-fold (verapamil) higher. Verapamil and rociverine, but not the other drugs, were also active on ileum. N-Butylscopolammonium bromide [149-64-4], phloroglucinol [108-73-6] and trimebutine maleate [34140-59-5] were inactive against the contraction of the 3 intestinal regions, and prifinium bromide [4630-95-9] was inactive on duodenum and ileum, while having remarkable activity on colon (unrelated to its antimuscarinic activity). The results are discussed briefly with ref. to the pharmacol. therapy of the irritable bowel syndrome.

Prophylactic and curing effect of ganglion blocking substances and atropine on mice, rats, guinea pigs, and dogs intoxicated by organic phosphorus compounds as insecticides: Prophylactic and curing effect of ganglion blocking substances and atropine on mice, rats, guinea pigs, and dogs intoxicated by organic phosphorus compounds as insecticides. Aytug, Cemal N. (Ankara Univ., Ankara, Turk.). Istanbul Univ. Vet. Fak. Derg., 2(1), 65-84 (Turkish) 1976. CODEN: IUVDD7. 60-40-2 and 51-55-8 which are cas registry numbers of chemicals are mentioned. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The prophylactic and therapeutic effect of the ganglion blocking agents mecamylamine [60-40-2], hexamethonium [60-26-4], buscopan [149-64-4] and toxogonin [114-90-9] and atropine [51-55-8] or their combinations on Et parathion (I) [56-38-2], gusathion [86-50-0], or neguvon (II) [52-68-6] poisoning was studied in mice, rats, guinea pigs, and dogs. A combination of atropine and mecamylamine or atropine, buscapan and hexamethionium administered 15 min prior to I or II administration was the most effective in preventing I or II poisoning. Atropine was more effective than mecamylamine or hexamethionium alone. Combinations of atropine and toxogonin, atropine, and buscopan, and atropine, buscopan, and mecamylamine had no effect. .

Detail of "149-64-4"

3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,9-butyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-, bromide (1:1), (1a,2b,4b,5a,7b)-

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CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

CAS No.149-64-4 Scopolamine butylbromide

Reference