Reference

The influence of betamethasone on the feto-placental unit

The influence of betamethasone on the feto-placental unit. A preliminary report. Negulescu, Radu I.; Strecker, Juergen R.; Lauritzen, Christian; Pal, Shrikantabushan (Dep. Obstet. Gynecol., Univ. Ulm, Ulm, Ger.). J. Perinat. Med., 5(3), 120-32 (English) 1977. CODEN: JPEMAO. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Section cross-reference(s): 6 Three h after betamethasone Na phosphate (I Na phosphate) [151-73-5] (12 mg, i.m.) was administered maternal plasma estradiol [50-28-2] levels were decreased by 69 and 33% and estriol [50-27-1] by 63 and 42% in women with normal and pathol. 3rd trimester pregnancies, resp. Estrogen values returned to basal values 3 days after I injection in normal pregnancies and 5 days in pathol. pregnancies. When dehydroepiandrosterone sulfate [651-48-9] (25 or 50 mg, i.v.) was administered 3 h after I, the increase in maternal plasma estradiol and estriol levels was greater in normal than in pathol. pregnancies. Changes in maternal plasma estrogen levels after treatment with I and dehydroepiandrosterone sulfate may be useful in monitoring the well being of the fetoplacental unit.

The effect of certain anti-inflammatory steroids on collagen synthesis in vitro

The effect of certain anti-inflammatory steroids on collagen synthesis in vitro. Saarni, Heikki (Dep. Med. Chem., Univ Turku, Turku, Finland). Biochem. Pharmacol., 26(21), 1961-6 (English) 1977. CODEN: BCPCA6. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Several antiinflammatory steroids and their derivs., but not dexamethasone (I) [50-02-2] or I monosodium phosphate [1869-92-7], at concns. of 10-3-10-7M, decreased collagen formation in chick embryo tendon cells. The amt. of labeled collagen decreased more in the medium than in the cells, but no steroid caused an accumulation of labeled collagen in the cells. Hydrocortisone (II) [50-23-7] was as inhibitory as hydrocortisone-17-butyrate [13609-67-1], but both were more effective than II Na succinate [125-04-2] or II monosodium phosphate [38048-30-5]. Betamethasone-17-valerate [2152-44-5] was the most potent inhibitor tested, but betamethasone (III) [378-44-9] and III disodium phosphate [151-73-5] were ineffective. Prednisolone [50-24-8] was as effective against collagen as II. The decrease in collagen followed the decrease in total labeled protein. Inhibition of collagen formation by antiinflammatory steroids may be a consequence of a general protein formation inhibition.