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15177-68-1

Basic Information
CAS No.: 15177-68-1
Name: Cyclohexanecarboxylic acid, 4-cyano-, trans-
Molecular Structure:
Molecular Structure of 15177-68-1 (Cyclohexanecarboxylic acid, 4-cyano-, trans-)
Formula: C8H11NO2
Molecular Weight: 153.181
Synonyms: trans-4-cyanocyclohexane-1-ylcarboxylic acid;trans-4-Cyan-cyclohexancarbonsaeure;Cyclohexanecarboxylic acid,4-cyano-,trans;trans-4-Cyan-cyclohexan-1-carbonsaeure;trans-4-cyanocyclohexanecarboxylic acid;
PSA: 61.09000
LogP: 1.40098
Synthetic route
6550-85-2

trans-1,4-cyclohexanedicarbonitrile

15177-68-1

trans-4-cyanocyclohexane-1-ylcarboxylic acid

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; potassium dihydrogenphosphate; Acremonium sp. D9K; Thiamine hydrochloride; magnesium sulfate; glycerol; sodium chloride; biotin In water at 30℃; Product distribution; at different pHs, effect of various carbon and nitrogen sources;
With dipotassium hydrogenphosphate; potassium dihydrogenphosphate; Acremonium sp. D9K; Thiamine hydrochloride; magnesium sulfate; glycerol; sodium chloride; biotin In water at 30℃;
concentrated ammonia water

concentrated ammonia water

15177-68-1

trans-4-cyanocyclohexane-1-ylcarboxylic acid

1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

Conditions
ConditionsYield
aluminum nickel In methanol; water; acetone92%
67-56-1

methanol

15177-68-1

trans-4-cyanocyclohexane-1-ylcarboxylic acid

19145-95-0

methyl trans-4-cyanocyclohexane-1-carboxylate

Conditions
ConditionsYield
With sulfuryl dichloride for 2h; Heating;
15177-68-1

trans-4-cyanocyclohexane-1-ylcarboxylic acid

87589-40-0

1-chloroethyl trans-4-cyanocyclohexanecarboxylate

87589-42-2

1,1-ethylidene bis(trans-4-cyanocyclohexanecarboxylate)

Conditions
ConditionsYield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate 2.) trichloroethylene, reflux, 8 h; Yield given. Multistep reaction;
With tetra(n-butyl)ammonium hydrogen sulfate In sodium hydroxide; Trichloroethylene
15177-68-1

trans-4-cyanocyclohexane-1-ylcarboxylic acid

4-Cyano-cyclohexanecarboxylic acid 1-chloro-propyl ester

87611-40-3

1,1-propandiol bis-(trans-4-cyanocyclohexanecarboxylate)

Conditions
ConditionsYield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate 2.) trichloroethylene, reflux, 8 h; Multistep reaction;
15177-68-1

trans-4-cyanocyclohexane-1-ylcarboxylic acid

63136-90-3

4-Cyano-cyclohexanecarbonyl chloride

Conditions
ConditionsYield
With thionyl chloride for 0.5h; Heating;
31770-76-0

3-(4-hydroxyphenyl)propionic acid benzyl ester

15177-68-1

trans-4-cyanocyclohexane-1-ylcarboxylic acid

122224-25-3

4-Cyano-cyclohexanecarboxylic acid 4-(2-benzyloxycarbonyl-ethyl)-phenyl ester

Conditions
ConditionsYield
(i) SOCl2, (ii) /BRN= 2217949/, Et3N; Multistep reaction;
15177-68-1

trans-4-cyanocyclohexane-1-ylcarboxylic acid

87589-40-0

1-chloroethyl trans-4-cyanocyclohexanecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfurous oxychloride / 0.5 h / Heating
2: ZnCl2 / 1.5 h / 90 °C
View Scheme
15177-68-1

trans-4-cyanocyclohexane-1-ylcarboxylic acid

4-Cyano-cyclohexanecarboxylic acid 1-chloro-propyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfurous oxychloride / 0.5 h / Heating
2: ZnCl2 / 1.5 h / 90 °C
View Scheme
15177-68-1

trans-4-cyanocyclohexane-1-ylcarboxylic acid

(1-pivaloyloxy)ethyl trans-4-cyanocyclohexanecarboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfurous oxychloride / 0.5 h / Heating
2: ZnCl2 / 1.5 h / 90 °C
3: 1.) tetrabutylammonium hydrogen sulfate (QHSO4), 2 M aq. NaOH / 2.) trichloroethylene, reflux, 8 h
View Scheme
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    Cyclohexanecarboxylic acid, 4-cyano-, trans-

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    Cyclohexanecarboxylic acid, 4-cyano-, trans-

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    Cyclohexanecarboxylic acid, 4-cyano-, trans-

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    trans-4-cyanocyclohexane-1-ylcarboxylic acid

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  • trans-4-Cyanocyclohexanecarboxylic acid CAS No.15177-68-1

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    trans-4-Cyanocyclohexanecarboxylic acid CAS No.15177-68-1

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    Trans-4-cyanocyclohexanecarboxylic acid

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