Detail of "154-23-4"

CAS Number:
154-23-4
Name:
2H-1-Benzopyran-3,5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)-
Superlist Name:
Cianidanol
Molecular Structure:
Formula:
C₁₅H₁₄O₆
Molecular Weight:
290.29
Deleted CAS:
159761-73-6,16198-00-8,321-01-7,4211-28-3,5323-80-8
Synonyms:
2H-1-Benzopyran-3,5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-trans)-;(+)-(2R:3S)-5,7,3',4'-Tetrahydroxyflavan-3-ol;(+)-Catechin;(+)-Cianidanol;Catechinic acid;Catergen;Cyanidanol;D-(+)-Catechin;D-Catechol;NSC 2819;Teafuran 30A;
EINECS:
205-825-1
Density:
1.593 g/cm³
Melting Point:
175-177 °C (anhydrous)(lit.)
Boiling Point:
630.4 °C at 760 mmHg
Flash Point:
335 °C
Appearance:
Tan solid
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety:
26-36 Details

Famous Chemical Enterprises

Livzon
Total
Shell
Dupont
Exxonmobil
Akzonobel
Basf
Bayer
BP

Other Products

Supplier Location
Supplier Location
- China (Mainland)(17)
- United States(4)
- Denmark(1)
- Germany(1)
- India(1)
- Japan(1)
Business Type
Business Type
- Lab/Research institutions(3)
- Manufacturers(1)
- Other(1)
- Trading Company(17)
Certificates
Certificates
- ISO(1)
- Production License(1)

Please post your buying leads>>

Display：

Manufacturer
Enterprise Authentication
Suppiers of more reward points first
New supplier

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Reference

Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids: Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids. Huang, Mou Tuan; Wood, Alexander W.; Newmark, Harold L.; Sayer, Jane M.; Yagi, Haruhiko; Jerina, Donald M.; Conney, Allan H. (Dep. Biochem. Drug Metab., Hoffmann-La Roche Inc., Nutley, NJ 07110, USA). Carcinogenesis (London), 4(12), 1631-7 (English) 1983. CODEN: CRNGDP. ISSN: 0143-3334. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Myricetin [529-44-2], robinetin [490-31-3], and luteolin [491-70-3] inhibited the mutagenic activity resulting from the metabolic activation of benzo[a]pyrene (I) [50-32-8] and (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene [61443-57-0] by rat liver microsomes. These naturally occurring plant flavonoids and 17 addnl. flavonoids and related derivs. with phenolic hydroxyl groups inhibited the mutagenic activity of (±)-7b,8a-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo[a]pyren e (B[a]P 7,8-diol-9,10-epoxide-2) [58917-67-2], which is an ultimate mutagenic and carcinogenic metabolite of I. Several flavonoids without phenolic hydroxyl groups of methylated phenolic hydroxyl groups were inactive. The mutagenic activity of 0.05 nmol BP 7,8-diol-9,10-epoxide-2 towards strain TA 100 of Salmonella typhimurium was inhibited 50% by incubation of the bacteria and the diol-epoxide with myricetin (2nmol), luteolin (5 nmol), quercetin [117-39-5] (5 nmol), 7-methoxyquercetin [90-19-7] (5 nmol), rutin [153-18-4] (5 nmol), quercitrin [522-12-3] (5 nmol), delphinidin chloride [528-53-0] (5 nmol), morin [480-16-0] (10 nmol), myricitrin [17912-87-7] (10 nmol), kaempferol [520-18-3] (10 nmol), diosmetin [520-34-3] (10 nmol), fisetin [528-48-3] (10 nmol), or apigenin [520-36-5] (10 nmol). Considerably less antimutagenic activity was obsd. for dihydroquercetin [480-18-2], naringenin [480-41-1], robinin [301-19-9], D-catechin [154-23-4], genistein [446-72-0], kaempferide [491-54-3], and chrysin [480-40-0]. Pentamethoxyquercetin [1247-97-8], tangeretin [481-53-8], nobiletin [478-01-3], 7,8-benzoflavone [604-59-1], 5,6-benzoflavone [6051-87-2], and flavone [525-82-6], which lack free phenolic groups, were inactive. The antimutagenic activity of hydroxylated flavonoids results from their direct interaction with B[a]P 7,8-diol-9,10-epoxide-2 since the rate of disappearance of the diol-epoxide from cell-free solns. in 1:9 dioxane:water was markedly stimulated by myricetin, robinetin, and quercetin. Myricetin was a highly potent inhibitor of the mutagenic activity of bay-region diol-epoxides of I, dibenzo[a,h]pyrene and dibenzo[a,i]pyrene, but higher concns. of myricetin were needed to inhibit the mutagenicity of the chem. less reactive benzo[a]pyrene 4,5-oxide and bay region diol-epoxides of benz[a]anthracene, chrysene, and benzo[c]phenanthrene.

Alloxan-induced diabetes in the rat - protective action of (-)epicatechin?: Alloxan-induced diabetes in the rat - protective action of (-)epicatechin?. Ryle, P. R.; Barker, J.; Gaines, P. A.; Thomson, A. D.; Chakraborty, J. (Dep. Gastroenterol., Greenwich District Hosp., London SE1O 9HE, UK). Life Sci., 34(6), 591-5 (English) 1984. CODEN: LIFSAK. ISSN: 0024-3205. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Administration of either (-)epicatechin [490-46-0] or (+)catechin [154-23-4] (250 mg/kg, i.p.) at 36, 24, 12 and 1 h before and at 12 and 24 h after alloxan administration did not prevent the induction of the diabetes. Similarly, treatment of animals with (-)epicatechin or (+)cathechin (125 mg/kg i.p. twice daily) for 21 days commencing 24 h after alloxan administration did not reverse the persisting elevated serum glucose and low serum insulin concns. Moreover, administration of these compds. did not relieve any of the symptoms of the alloxan-induced diabetes such as poor wt. gain, polyuria or polydipsia.

Detail of "154-23-4"

2H-1-Benzopyran-3,5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)-

Famous Chemical Enterprises

Related products

Other Products

Supplier Location

Business Type

Certificates

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

CAS No.154-23-4 Cianidanol

Reference