Detail of "156-51-4"

Reference

Influence of MAO inhibitors on uptake and release of norepinephrine in rat brain in vitro

Influence of MAO inhibitors on uptake and release of norepinephrine in rat brain in vitro. Ziance, R. J.; Moxley, K.; Mullis, M.; Gray, W. (Sch. Pharm., Univ. Georgia, Athens, Ga., USA). Arch. Int. Pharmacodyn. Ther., 228(1), 30-8 (English) 1977. CODEN: AIPTAK. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Monoamine oxidase (MAO) [9001-66-5] inhibitors of diverse chem. structures inhibited the uptake of 3H-labeled norepinephrine (NE) [51-41-2] into chopped rat cerebral cortex in vitro. The following molar (M) IC50 values to inhibit NE uptake were obtained: iproniazid [54-92-2], 7.9 ′ 10-4M; pargyline-HCl [306-07-0] 3.1 ′ 10-4M; pheniprazine [55-52-7], 6.3 ′ 10-6M; phenelzine sulfate [156-51-4], 3.9 ′ 10-6M; tranylcypromine sulfate [13492-01-8], 2.5 ′ 10-6M; d-amphetamine sulfate [51-63-8], 2.5 ′ 10-7M. In addn. to decreasing deaminative catabolism, 5 ′ 10-5M amphetamine, tranylcypromine and pheniprazine plus 10-3M phenelzine produced a release of 3H-NE from tissue stores into incubation media. Similar concns. of pargyline and iproniazid were ineffective to release 3H-NE from brain tissue.

Interaction of selective inhibitors of monoamine oxidase with pethidine in rabbits

Interaction of selective inhibitors of monoamine oxidase with pethidine in rabbits. Jounela, Antti J.; Mattila, Mauri J.; Knoll, Joseph (Dep. Med., Oulu Univ. Hosp., Oulu, Finland). Biochem. Pharmacol., 26(8), 806-8 (English) 1977. CODEN: BCPCA6. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Pretreatment of rabbits with phenelzine hydrogen sulfate [156-51-4] (5 mg/kg, s.c.) 10 h before i.v. injection of pethidine-HCl [50-13-5] (1.25 mg/kg), increased hypothalamic 5-hydroxytryptamine (I) [50-67-9] and decreased hypothalamic 5-hydroxyindoleacetic acid (I) [54-16-0]; pethidine caused excitation, hyperthermia, and sometimes death in the phenelzine-pretreated rabbits. Pretreatment of rabbits with clorgyline-HCl [17780-75-5] (5 or 20 mg/kg, s.c.) 10 h before pethidine increased I and lowered II but there were no behavioral or temp. effects. 1-Deprenyl-HCl [14611-52-0] (5 mg/kg, s.c.)-pretreatment increased I and lowered II in the hypothalamus; pethidine induced behavioral and temp. effects in some of the deprenyl-pretreated animals. Pretreatment of rabbits with clorgyline and deprenyl (5 mg/kg of both drugs, s.c.) 10 h before pethidine resulted in high I and very low II levels in the hypothalamus; pethidine evoked a toxic reaction with excitatory and hyperthermic effects in these animals. Pretreatment of rabbits with both clorgyline and deprenyl are required to produce the toxic response to pethidine obsd. with phenelzine.