Reference

Evaluation of anxiolytic properties of Gotukola - (Centella asiatica) extracts and asiaticoside in rat behavioral models

All Rights Reserved. Evaluation of anxiolytic properties of Gotukola - (Centella asiatica) extracts and asiaticoside in rat behavioral models. Wijeweera, P.; Arnason, J. T.; Koszycki, D.; Merali, Z. (Ottawa-Carleton Institute of Biology, University of Ottawa, Can.). Phytomedicine, 13(9-10), 668-676 (English) 2006 Elsevier GmbH. CODEN: PYTOEY. ISSN: 0944-7113. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 63 The ayurvedic medicinal plant Gotukola (Centella asiatica) was evaluated for its anxiolytic properties. 16830-15-2 is the cas registry number of certain chemical which is used as reagents here. Specifically, this study assessed the effects of: Gotukola plant materials of different genotypic origin; hexane, Et acetate and methanol exts. of Gotukola; and asiaticoside, a triterpenic compd. isolated from Gotukola. Various paradigms were used to assess the anxiolytic activity, including the elevated plus maze (EPM), open field, social interaction, locomotor activity, punished drinking (Vogel) and novel cage tests. The EPM test revealed that Gotukola, its methanol and Et acetate exts. as well as the pure asiaticoside, imparted anxiolytic activity. Furthermore, the asiaticoside did not affect locomotor activity, suggesting these compds. do not have sedative effects in rodents. .

Genotoxicity study of AS6, a triterpenoid derivatives

Genotoxicity study of AS6, a triterpenoid derivatives. Kwon, Jung; Lee, Michael; Cha, Kyunghoi; Kim, Jong-Choon; Han, Junghee (Korea Institute of Toxicology, KRICT, Yuseong, Daejon 305-600, S. Korea). Journal of Applied Pharmacology, 11(3), 190-195 (English) 2003 Korean Society of Applied Pharmacology. CODEN: JOAPA6. ISSN: 1225-6110. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) To assess the genotoxicity of AS6, several classical toxicol. tests were performed. In Ames test, AS6 did not show any transformation of revertant with or without S-9 metabolic activating system, indicating the lack of mutagenic effect of the compd. To assess clastogenic effect, in vivo micronucleus and in vitro chromosomal aberration assays were performed using male ICR mice and Chinese hamster lung (CHL) fibroblast cells, resp. 16830-15-2 which is the cas registry number of some chemical is mentioned. Chromosomal aberration was not induced regardless of the presence of S-9 metabolic activating system. In addn., AS6 did not cause any increase in the incidence of micronucleated polychromatic erythrocytes at any of the dose levels, suggesting little clastogenicity in vitro or in vivo. Taken together, these results demonstrate that AS-6 has no mutagenic effect in our test system. .