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CAS No.: | 18694-40-1 |
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Name: | Epirizole |
Article Data: | 12 |
Molecular Structure: | |
Formula: | C11H14 N4 O2 |
Molecular Weight: | 234.258 |
Synonyms: | Pyrimidine,4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methyl- (8CI); 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole;1-(4-Methyl-6-methoxy-2-pyrimidinyl)-3-methyl-5-methoxypyrazole;2-(3-Methoxy-5-methylpyrazol-2-yl)-4-methoxy-6-methylpyrimidine;2-(3-Methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methylpyrimidine; 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine;DA 398; Epirizole; Mebron; Mepirizole |
EINECS: | 242-507-1 |
Density: | 1.25g/cm3 |
Melting Point: | 90-92° |
Boiling Point: | 444°Cat760mmHg |
Flash Point: | 222.3°C |
Appearance: | Yellow power |
Hazard Symbols: | |
Risk Codes: | R20/21/22;R36/37/38 |
Safety: | Poison by subcutaneous, intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. |
PSA: | 62.06000 |
LogP: | 1.29630 |
Product Name: Mepirizol (CAS NO.18694-40-1)
Molecular Formula: C11H14N4O2
Molecular Weight: 234.25g/mol
Mol File: 18694-40-1.mol
Einecs: 242-507-1
Appearance: White or cream-colored crystals
Boiling point: 444 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 222.3 °C
Density: 1.25 g/cm3
Surface Tension: 40.1 dyne/cm
Enthalpy of Vaporization: 70.17 kJ/mol
Vapour Pressure: 4.43E-08 mmHg at 25°C
XLogP3: 1.3
H-Bond Donor: 0
H-Bond Acceptor: 5
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 540mg/kg (540mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978. |
mouse | LD50 | intravenous | 550mg/kg (550mg/kg) | Japan Medical Gazette. Vol. 7(9), Pg. 5, 1970. | |
mouse | LD50 | oral | 740mg/kg (740mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978. |
mouse | LD50 | subcutaneous | 550mg/kg (550mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 494, 1977. | |
rat | LD50 | intraperitoneal | 214mg/kg (214mg/kg) | Japan Medical Gazette. Vol. 7(9), Pg. 5, 1970. | |
rat | LD50 | intravenous | 214mg/kg (214mg/kg) | "Modern Pharmaceuticals of Japan, V," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1975Vol. -, Pg. 87, 1975. | |
rat | LD50 | oral | 445mg/kg (445mg/kg) | Japan Medical Gazette. Vol. 7(9), Pg. 5, 1970. | |
rat | LD50 | subcutaneous | 208mg/kg (208mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 494, 1977. |
Poison by subcutaneous, intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of Mepirizol (CAS NO.18694-40-1):
Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
Mepirizol ,its CAS NO. is 18694-40-1,the synonyms is 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole ; 2-(3-Methoxy-5-methylpyrazol-2-yl)-4-methoxy-6-methylpyrimidine ; 2-(3-Methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methylpyrimidine ; 4-Methoxy-2-(5-methoxy-3-methyl-1h-pyrazol-1-yl)-6-methyl-pyrimidin ; 4-Methoxy-2-(5-methoxy-3-methyl-1h-pyrazol-1-yl)-6-methylpyrimidine ; 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin ; Da-398 ; Mebron .