Reference

Comparison of aerosolized atropine sulfate and Sch 1000 on exercise-induced bronchospasm in children

Comparison of aerosolized atropine sulfate and Sch 1000 on exercise-induced bronchospasm in children. Borut, Thomas C.; Tashkin, Donald P.; Fischer, Thomas J.; Katz, Roger; Rachelefsky, Gary; Siegel, Sheldon C.; Lee, Enoch; Harper, Charles (Dep. Pediatr. Med., Univ. California Med. Cent., Los Angeles, Calif., USA). J. Allergy Clin. Immunol., 60(2), 127-33 (English) 1977. CODEN: JACIBY. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 14 The effectiveness of different doses of nebulized Sch 1000 (I) [22254-24-6] (40 .mu.g and 80 .mu.g), aerosolized atropine sulfate [55-48-1] (1 mg), and placebo in the prevention of exercise-induced bronchospasm (EIB) in children with atopic bronchial asthma were studied. Following no treatment or placebo, exercise resulted in av. redns. of 33% to 43% in plethysmographic specific airway conductance (SGaw), of 20% to 25% in forced expiratory vol. in 1 sec, and of 25% to 32% in max. midexpiratory flow rate. Exercise following no treatment or placebo resulted in av. increases of 23% to 30% in thoracic gas vol. Prior to exercise atropine and either dose of I increased SGaw (48% to 59%). After pretreatment with I or atropine, exercise caused SGaw to fall to values that were not significantly different from pretreatment medication values, but were significantly higher than values following exercise without pretreatment or after pretreatment with placebo. No significant differences were noted between the effects of atropine and I on EIB. Thus, at the doses used atropine and I cause equiv. degrees of bronchodilation but neither drug specifically inhibits EIB.

Ipratropium bromide: mucociliary clearance rate and airway resistance in normal subjects

Ipratropium bromide: mucociliary clearance rate and airway resistance in normal subjects. Francis, Rupert A.; Thomson, Maurice L.; Pavia, Demetri; Douglas, Robert B. (London Sch. Hyg. Trop. Med., TUC Centen. Inst. Occup. Health, London, Engl.). Br. J. Dis. Chest, 71(3), 173-8 (English) 1977. CODEN: BJDCAT. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The effect of ipratropium bromide (I) [22254-24-6], a new anticholinergic drug, on the rate of clearance of secretions from the lung and on airway resistance was investigated in 12 healthy subjects in a double-blind cross-over trial with placebo and a control run without aerosol. Before taking the drug the subjects inhaled uniform 5 .mu.m tracer particles of polystyrene in which 99mTc had been unleachably incorporated. The initial depth of deposition and the rate of clearance of the particles were obtained from serial .gamma. counts made externally to the chest over 6 h. The difference between drug, placebo and control runs in the deposition patterns of the tracer particles and their subsequent rates of clearance were not significant. The drug treatment resulted in decreases in specific airway resistance at 1, 2, 3 and 6 h. There was no objective or subjective evidence of side effects from the drug.