Reference

The effect of diflunisal administration on platelet aggregation and cerebral blood flow

The effect of diflunisal administration on platelet aggregation and cerebral blood flow. Mikhailidis, D. P.; Barradas, M. A.; Temple-Savage, I.; Streete, P. J.; Henry, J. A.; James, I. M.; Dandona, P. (Dep. Chem. Pathol., R. Free Hosp., London, UK). Pharmatherapeutica, 4(4), 255-9 (English) 1985. CODEN: PHARDW. ISSN: 0308-051X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effect of a high dose of diflunisal [22494-42-4] (750 mg twice daily) on platelet aggregation and cerebral blood flow was investigated in volunteers. Diflunisal inhibited platelet aggregation consistently; this effect on platelets was markedly diminished within 24 h after the last dose of diflunisal. There was, however, no correlation between the antiaggregatory effect of diflunisal and its plasma concn. Diflunisal did not alter cerebral blood flow.

Glucuronidation and elimination of diflunisal in the isolated perfused rat liver: effect of pretreatment with phenobarbitone, clofibric acid and spironolactone

Glucuronidation and elimination of diflunisal in the isolated perfused rat liver: effect of pretreatment with phenobarbitone, clofibric acid and spironolactone. Faed, E. M.; Dobbs, B. R.; Lee, D. (Sch. Med., Univ. Otago, Dunedin, N. Z.). Arch. Int. Pharmacodyn. Ther., 272(1), 4-16 (English) 1984. CODEN: AIPTAK. ISSN: 0003-9780. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of pretreatment of rats with phenobarbitone [50-06-6], clofibric acid [882-09-7], and spironolactone [52-01-7] on the metab. and biliary excretion of the salicylate deriv. diflunisal (I) [22494-42-4] were studied using the isolated perfused liver. The clearance of I was increased by pretreatment with each of the drugs. Biliary excretion of I acyl and phenolic glucuronides followed apparent 1st-order and Michaelis-Menten kinetics, resp. Pretreatment with clofibric acid or spironolactone resulted in an increase in the biliary excretion of the phenolic glucuronide. Pretreatment with phenobarbitone or spironolactone enhanced biliary excretion of the acyl glucuronide, particularly during the 1st 2 h. The concn. of the phenolic glucuronide in the perfusate increased steadily during the 6-h perfusions, whereas the acyl glucuronide concn. was relatively stable, reflecting the ease of hydrolysis of acyl glucuronides under physiol. conditions.