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| CAS No.: | 22677-21-0 |
|---|---|
| Name: | 2-Pyrrolidinone,4-hydroxy-, (4R)- |
| Article Data: | 23 |
| Molecular Structure: | |
|
|
|
| Formula: | C4H7NO2 |
| Molecular Weight: | 101.105 |
| Synonyms: | 2-Pyrrolidinone,4-hydroxy-, (R)- (8CI);(4R)-4-Hydroxy-2-pyrrolidinone;(4R)-4-Hydroxypyrrolidin-2-one;(R)-4-Hydroxy-2-pyrrolidinone;(R)-4-Hydroxypyrrolidin-2-one; |
| Density: | 1.292 g/cm3 |
| Melting Point: | 156-160 °C |
| Boiling Point: | 363.6 °C at 760 mmHg |
| Flash Point: | 173.7 °C |
| Solubility: | Slightly soluble in water. |
| Appearance: | white to light yellow crystal powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26 |
| PSA: | 49.33000 |
| LogP: | -0.80400 |
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- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
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- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 240444-70-62,3,5,6-Tetrafluor-4-(methoxymethyl)benzyl-2,2-dimethyl-3-(prop-1-en-1-yl)cyclopropancarboxylat
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 10488-69-4, 86728-85-0, 87068-18-6, 90866-33-4
ethyl (L)-4-chloro-3-hydroxybutyrate
- 22677-21-0
(R)-4-hydroxy-2-pyrrolidinone
| Conditions | Yield |
|---|---|
| With ammonium hydroxide at 80℃; for 3h; | 82% |
- 135056-42-7
1-(1'-phenylethyl)-4-phenylmethoxypyrrolidin-2-one
- 22677-21-0
(R)-4-hydroxy-2-pyrrolidinone
| Conditions | Yield |
|---|---|
| With ammonia; sodium In tetrahydrofuran for 1h; | 51% |
- 131653-48-0
(4R)-4-hydroxy-1-<(1S)-1-phenylethyl>pyrrolidin-2-one
- 22677-21-0
(R)-4-hydroxy-2-pyrrolidinone
| Conditions | Yield |
|---|---|
| With ammonia; lithium In tetrahydrofuran; tert-butyl alcohol at -60℃; for 0.25h; |
- 22677-21-0
(R)-4-hydroxy-2-pyrrolidinone
| Conditions | Yield |
|---|---|
| With sulfuric acid; dihydrogen peroxide at 40℃; for 0.75h; Yield given; |
- 22677-21-0
(R)-4-hydroxy-2-pyrrolidinone
- 208103-39-3
3(R)-hydroxy-4-aminobutyric acid ethyl ester
- 22677-21-0
(R)-4-hydroxy-2-pyrrolidinone
| Conditions | Yield |
|---|---|
| In ethanol |
- 22677-21-0
(R)-4-hydroxy-2-pyrrolidinone
| Conditions | Yield |
|---|---|
| In methanol |
- 22677-21-0
(R)-4-hydroxy-2-pyrrolidinone
- 18162-48-6
tert-butyldimethylsilyl chloride
- 131653-51-5
(4R)-4-((tert-butyl(dimethyl)silyl)oxy)pyrrolidin-2-one
| Conditions | Yield |
|---|---|
| With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 0.5h; Condensation; | 99% |
| With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 12h; | 95% |
| With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 3h; | 91% |
- 22677-21-0
(R)-4-hydroxy-2-pyrrolidinone
- 58479-61-1
tert-butylchlorodiphenylsilane
- 945635-00-7
(R)-4-[tert-butyl(diphenyl)silanyloxy]pyrrolidin-2-one
| Conditions | Yield |
|---|---|
| With 1H-imidazole In N,N-dimethyl-formamide at 0℃; for 0.5h; | 96% |
- 22677-21-0
(R)-4-hydroxy-2-pyrrolidinone
- 7013-07-2
(R)-4-Amino-3-hydroxybutanoic acid
| Conditions | Yield |
|---|---|
| With hydrogenchloride for 4h; Heating; | 94% |
| With lithium hydroxide for 24h; Ambient temperature; | 89% |
| With hydrogenchloride for 2h; Heating; | 70% |
| With barium dihydroxide | |
| With hydrogenchloride for 10h; Heating; Yield given; |
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Chemistry
IUPAC Name: (4R)-4-Hydroxypyrrolidin-2-one
Synonyms of (R)-(+)-4-hydroxy-2-pyrrolidinone (CAS NO.22677-21-0): (R)-4-Hydroxy-2-pyrrolidinone ; (R)-Beta-Hydroxy-gamma-butyrolactam ; 2-Pyrrolidinone, 4-hydroxy-, (R) ; (R)-4-Hydoroxyoyrolidone ; 4-Hydroxy-R-2-pyrrolidine
CAS NO: 22677-21-0
Molecular Formula: C4H7NO2
Molecular Weight: 101.1
Molecular Structure: 
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 29.54Å2
Index of Refraction: 1.513
Molar Refractivity: 23.51 cm3
Molar Volume: 78.2 cm3
Surface Tension: 50.8 dyne/cm
Density: 1.292 g/cm3
Flash Point: 173.7 °C
Enthalpy of Vaporization: 70.57 kJ/mol
Boiling Point: 363.6 °C at 760 mmHg
Vapour Pressure: 9.26E-07 mmHg at 25°C
Melting Point: 156-160 °C
Appearance: white to light yellow crystal powder
SMILES: O=C1NC[C@H](O)C1
InChI: InChI=1/C4H7NO2/c6-3-1-4(7)5-2-3/h3,6H,1-2H2,(H,5,7)/t3-/m1/s1
InChIKey: IOGISYQVOGVIEU-GSVOUGTGBE
Std. InChI: InChI=1S/C4H7NO2/c6-3-1-4(7)5-2-3/h3,6H,1-2H2,(H,5,7)/t3-/m1/s1
Std. InChIKey: IOGISYQVOGVIEU-GSVOUGTGSA-N
Product Categories of (R)-(+)-4-hydroxy-2-pyrrolidinone (CAS NO.22677-21-0): Drug Intermediates;Pyrrole&Pyrrolidine&Pyrroline
Safety Profile
Safety Information of (R)-(+)-4-hydroxy-2-pyrrolidinone (CAS NO.22677-21-0):
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3