Reference

Clinical testing of the local anesthetic Hoe 40045 (Ultracain) in calving and gynecologic operations as well as teat surgery in dairy cattle

Clinical testing of the local anesthetic Hoe 40045 (Ultracain) in calving and gynecologic operations as well as teat surgery in dairy cattle. Weichel, D.; Ahlers, D. (Klin. Geburtshilfe Gynaekol. Rindes, Tieraerztl. Hochsch. Hannover, Hannover, Ger.). Dtsch. Tieraerztl. Wochenschr., 84(6), 240-2 (German) 1977. CODEN: DTTIAF. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Ultracaine [23964-57-0] (4% solns.) is a highly effective local anesthetic during calving and gynecol. operations in cattle. For infiltration of the abdominal wall for section delivery, 100-120 mL is recommended, whereas 10-25 mL is recommended for teat surgery. Lower doses are recommended for extradural anesthesia: 2-2.5 mL for section delivery; 15 mL for fetotomy in lying animals; 3 mL for fetotomy in standing animals; 2 mL for correction of displacement of the fetus; 3.5-5 mL for surgery of the vulva, vestibulum, or vagina.

The anesthetic efficacy of 4 percent articaine 1:200,000 epinephrine: two controlled clinical trials

All Rights Reserved. The anesthetic efficacy of 4 percent articaine 1:200,000 epinephrine: two controlled clinical trials. Moore, Paul A.; Boynes, Sean G.; Hersh, Elliot V.; DeRossi, Scott S.; Sollecito, Thomas P.; Goodson, J. Max; Leonei, Juliana S.; Floros, Constantinos; Peterson, Carrie; Hutcheson, Matthew (Department of Anesthesiology, Oral Health Science Institute, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA). Journal of the American Dental Association, JADA, 137(11), 1572-1581 (English) 2006 ADA Publishing. CODEN: JADSAY. ISSN: 0002-8177. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Objective: The authors conducted two double-blinded, randomized, multicenter clin. trials to det. the efficacy and clin. anesthetic characteristics of 4 percent articaine hydrochloride (HCl) with 1:200,000 epinephrine (A200) as compared with those of 4 percent articaine HCl with 1:100,000 epinephrine (A100) and 4 percent articaine HCl without epinephrine (Aw/o).Several substances with their cas registry numbers 23964-57-0 and 51-43-4 may be metioned in this study. Methods: During sep. testing sessions, members of the authors' research team used three articaine study formulations to induce either inferior alveolar nerve block anesthesia (Trial 1) or maxillary infiltration anesthesia (Trial 2). In each trial, subjects received, in a randomized sequence, each of the three formulations to det. efficacy (success rate) and anesthetic characteristics (onset time and duration). The authors evaluated pulpal anesthesia via subjects' response to elec. pulp testing (EPT). Results: A total of 126 subjects were enrolled in the two studies (63 subjects in each trial). In both mandibular and maxillary trials, the success rates for inducing profound anesthesia (EPT score 3 80), the mean onset times and the mean durations of anesthesia were similar for both epinephrine-contg. formulations (A200 and A100). In subjects who received the formulation contg. no epinephrine (Aw/o), the success rate for profound anesthesia was significantly less. Conclusion: These studies demonstrated that the inclusion of epinephrine in 4 percent articaine anesthetic formulations is essential for achieving profound anesthesia. The authors found that the A200 formulation provided a level of pulpal anesthesia comparable with that of the A100 formulation. .