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| CAS No.: | 24143-17-7 |
|---|---|
| Name: | OXAZOLAM METHANOL SOLUTION |
| Article Data: | 15 |
| Molecular Structure: | |
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| Formula: | C18H17 Cl N2 O2 |
| Molecular Weight: | 328.798 |
| Synonyms: | Hializan;Oxazolam; Oxazolazepam; Serenal; Serenal (Japanese); Tranquit |
| Density: | 1.37g/cm3 |
| Melting Point: | 187°C |
| Boiling Point: | 495.8°C at 760 mmHg |
| Flash Point: | 253.7°C |
| Hazard Symbols: | F,T |
| Risk Codes: | 11-23/24/25-39/23/24/25-36/38-23/25 |
| Safety: | Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl− and NOx. |
| PSA: | 45.06000 |
| LogP: | 3.23690 |
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Chemistry
IUPAC Name: 10-Chloro-2-methyl-11b-phenyl-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
Synonyms of Oxazolazepam (CAS NO.24143-17-7) : 10-Chloro-2,3,7,11b-tetrahydro-2-methyl-11b-phenyloxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one ; Benzo(6,7)-1,4-diazepino-(5,4-b)-oxazol-6-one, 10-chloro-2,3,5,6,7,11b-hexahydro-2-methyl-11b-phenyl- ; Oxazolam ; Oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one, 10-chloro-2,3,7,11b-tetrahydro-2-methyl-11b-phenyl-
CAS NO: 24143-17-7
Molecular Formula:C18H17ClN2O2
Molecular Weight :328.79278
Molecular Structure :
EINECS: 246-032-0
Index of Refraction: 1.668
Surface Tension: 60.5 dyne/cm
Density: 1.37 g/cm3
Flash Point: 253.7 °C
Enthalpy of Vaporization: 76.34 kJ/mol
Boiling Point: 495.8 °C at 760 mmHg
Vapour Pressure: 5.71E-10 mmHg at 25°C
Uses
Oxazolazepam (CAS NO.24143-17-7) is used as intermediate in organic synthesis.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 768mg/kg (768mg/kg) | "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 91, 1972. | |
| mouse | LD50 | oral | 5200mg/kg (5200mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 66, Pg. 107, 1970. | |
| mouse | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 91, 1972. | |
| rat | LD50 | intraperitoneal | > 2gm/kg (2000mg/kg) | "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 91, 1972. | |
| rat | LD50 | oral | > 4gm/kg (4000mg/kg) | "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 91, 1972. | |
| rat | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 91, 1972. |
Safety Profile
Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When Oxazolazepam (CAS NO.24143-17-7) is heated to decomposition, it emits toxic fumes of Cl− and NOx.