Detail of "24143-17-7"

CAS Number:
24143-17-7
Name:
Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one,10-chloro-2,3,7,11b-tetrahydro-2-methyl-11b-phenyl-
Molecular Structure:
Formula:
C18H17 Cl N2 O2
Molecular Weight:
328.82
Synonyms:
Hializan;Oxazolam; Oxazolazepam; Serenal; Serenal (Japanese); Tranquit
Safety:
Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl⁻ and NO_x. Details

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The behavior of 1,4-benzodiazepine drugs in the acidic media: The behavior of 1,4-benzodiazepine drugs in the acidic media. I. Proton and carbon 13 nuclear magnetic resonance spectra of oxazolam, cloxazolam and haloxazolam in the acidic media. Kuwayama, Tomonari; Yashiro, Tamotsu (Tokai Teishin Hosp., Nagoya 467, Japan). Yakugaku Zasshi, 104(6), 607-13 (Japanese) 1984. CODEN: YKKZAJ. ISSN: 0372-7750. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 22 Structural changes of oxazolam (I) [24143-17-7], cloxazolam (II) [24166-13-0] and haloxazolam (III) [59128-97-1] in an acidic aq. soln. 47267-80-1 is also in the experiment. (0.5N DCl) were investigated by 1H- and 13C-NMR spectroscopy. In acidic aq. solns. these compds. existed as iminium forms (IV) after rapid oxazolidine ring opening reaction and then, hydrolyzed at an iminium bond of 1,4-benzodiazepine ring to benzophenone compds. (V). But II remained as an iminium form under these conditions. Hydrolyzed products of I and III were isolated and their structures were detd. .

Behavioral pharmacology of antianxiety drugs: Behavioral pharmacology of antianxiety drugs. Kamioka, Toshiharu; Nakayama, Isao; Karube, Toshio (Biol. Res. Lab., Sankyo Co., Ltd., Japan). Neurosciences (Kobe, Jpn.), 9(2), 176-87 (Japanese) 1984. CODEN: NUOCDO. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Oxazolam [24143-17-7] and chlordiazepoxide [58-25-3] given orally to monkeys at 2 mg/kg increased the animals' sex activity, whereas mexazolam [31868-18-5] and diazepam [439-14-5] at 0.2 mg/kg did not. Studies on the effects of these 4 drugs on conflict and conditioned behavior revealed that all exerted similar qual. effects, but quant. different actions.