24143-17-7 Usage
Description
OXAZOLAM METHANOL SOLUTION is a psychotropic agent that possesses anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties. It serves as a precursor to the active substance Desmethyldiazepam (D291595), making it a valuable compound in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
OXAZOLAM METHANOL SOLUTION is used as a psychotropic agent for its anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties. It helps in the treatment of anxiety disorders, seizures, and muscle spasms, providing relief to patients suffering from these conditions.
Additionally, OXAZOLAM METHANOL SOLUTION is used as a precursor to the active substance Desmethyldiazepam (D291595), which further enhances its importance in the development of new medications and therapies in the pharmaceutical sector.
Originator
Serenal,Sankyo,Japan,1970
Manufacturing Process
To a solution of 12.0 g of 5-chloro-2-chloroacetylaminobenzophenone and 3.2 g of isopropanolamine in 100 ml of ethanol was added 3.3 g of sodium acetate.
The resulting mixture was heated under reflux with stirring for 12 hours. After completion of the reaction, the solvent was distilled off and the residue was extracted with dichloromethane. The extract was washed with water, dried over anhydrous sodium sulfate and the solvent was distilled off.
The residue was recrystallized from ethanol to give 10.6 g of the desired product melting at 186°C to 188.5°C.
Therapeutic Function
Tranquilizer
Safety Profile
Moderately toxic by intraperitoneal route. Mildly toxic by ingestion.An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Clí and NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 24143-17-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,1,4 and 3 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 24143-17:
(7*2)+(6*4)+(5*1)+(4*4)+(3*3)+(2*1)+(1*7)=77
77 % 10 = 7
So 24143-17-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H17ClN2O2/c1-12-10-21-11-17(22)20-16-8-7-14(19)9-15(16)18(21,23-12)13-5-3-2-4-6-13/h2-9,12H,10-11H2,1H3,(H,20,22)/t12-,18+/m1/s1
24143-17-7Relevant articles and documents
cis/trans Isomerization rate of oxazolam in organic solvents measured by high-performance liquid chromatography
Kurono,Jinno,Kuwayama,Sato,Yashiro,Ikeda
, p. 1044 - 1046 (2007/10/02)
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Intermediates for tricyclic benzodiazepines
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, (2008/06/13)
Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.
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